Tofacitinib Impurity 118 CAS 1615709-89-1
| CAS No. | 1615709-89-1 |
| Molecular Formula | C14H17N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Tofacitinib Impurity 118 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Tofacitinib Impurity 118 (CAS 1615709-89-1) is a certified pharmaceutical impurity reference standard with the molecular formula C14H17N2Br and a molecular weight of 293.21 g/mol.
The molecular framework of Tofacitinib Impurity 118 (C14H17N2Br) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Tofacitinib Impurity 118 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H17N2 Br |
| Molecular Weight | 293.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Tofacitinib Standards
- Tofacitinib Impurity 180 (CAS 100047-45-8)
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- Tofacitinib Impurity 182 (CAS 1053228-28-6)
- Tofacitinib Impurity 123 DiHCl (CAS 1062580-52-2)
- Tofacitinib Impurity 20 (CAS 1092578-43-2)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 1 (CAS 1092578-46-5)
- Tofacitinib Impurity 3 (CAS 1092578-47-6)
Recommended Standards
- Paliperidone Impurity 121 (CAS 24016-03-3)
- Glibenclamide EP Impurity B (CAS 21165-77-5)
- Benidipine Impurity 67 (CAS 105979-18-8)
- 2-Phenylpropane-1-sulfonamide (CAS 76653-16-2)
- 2,6-Dibromo-N-methylpyridin-3-amine (CAS 84539-50-4)
- Reactive Blue 5 (CAS 16823-51-1)
- 2-Chloro-1-(4-(dimethylamino)piperidin-1-yl)ethan-1-one (CAS 1154667-90-9)
- (S)-5-fluoro-1,2,3,4-tetrahydronaphthalen-2-amine (CAS 740779-66-2)
- Sodium cobalticarborane (CAS 99492-72-5)
- Peptide Impurity 13 (CAS CATO-CPTD788813)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com