Boc-2-(trifluoromethyl)-L-phenylalanine CAS 167993-21-7
| CAS No. | 167993-21-7 |
| Molecular Formula | C15H18F3NO4 |
| Molecular Weight | 333.30 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Boc-2-(trifluoromethyl)-L-phenylalanine.
Boc-2-(trifluoromethyl)-L-phenylalanine (CAS 167993-21-7), molecular formula C15H18F3NO4 and molecular weight 333.30 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, Boc-2-(trifluoromethyl)-L-phenylalanine (C15H18F3NO4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 333.30 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Boc-2-(trifluoromethyl)-L-phenylalanine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H18F3NO4 |
| Molecular Weight | 333.30 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Boc Standards
- Ethyl 5-(4-(trifluoromethyl)phenyl)-1H-indole-2-carboxylate (CAS 871927-70-7)
- Methyl 1-(3-(trifluoromethyl)benzyl)-1H-indole-2-carboxylate (CAS 860785-06-4)
- N-(3-(trifluoromethyl)benzyl)-2H-chromene-3-carboxamide (CAS 338420-01-2)
- 2-{[4-(trifluoromethyl)-2-pyridyl]oxy}ethyl 4-methyl-1,2,3-thiadiazole-5-carboxylate (CAS 257625-01-7)
- 3-[[[1-Methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]carbonyl]amino]-2-thiophenecarboxylic Acid Methyl Ester (CAS 293326-85-9)
- Bis({[3-(trifluoromethyl)phenyl]methyl})amine (CAS 863763-65-9)
- 1-Oxo-2-(4-(trifluoromethyl)phenyl)-1,2-dihydroisoquinoline-4-carboxylic acid (CAS 133096-33-0)
- 4-Oxo-3-(3-(trifluoromethyl)phenyl)-3,4-dihydrophthalazine-1-carboxamide (CAS 241127-33-3)
Recommended Standards
- 2-tert-Butoxycarbonylamino-3-(4-trifluoromethyl-phenyl)-propionic acid (CAS 167496-29-9)
- (2R,3R,4S,5R)-2-(6-Amino-8-(furan-2-yl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (CAS 547765-47-9)
- tert-Butyl 3-hydroxy-3-[2-(trifluoromethoxy)phenyl]azetidine-1-carboxylate (CAS 1609671-84-2)
- (E)-3,4-dihydronaphthalen-1(2H)-one O-(3-(trifluoromethyl)benzoyl) oxime (CAS 383148-83-2)
- Lithium Lactate (CAS 867-55-0)
- N-[3-(1H-imidazol-1-yl)propyl]-6-methyl-1,3-benzothiazol-2-amine (CAS 1177271-96-3)
- 6-Fluoro-1-methyl-1H-indole-3-carbaldehyde (CAS 441715-93-1)
- 4-Amino-N-(4-chlorophenyl)butanamide (CAS 938521-23-4)
- 3-(2,3-Dichlorophenoxy)azetidine hydrochloride (CAS 1955539-70-4)
- 2-(6-(tert-Butyl)-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-chlorobenzaldehyde (CAS 1242156-60-0)
- 5(S)-[1(S)-Azido-3(S)-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl]-3(S)-isopropyldihydrofuran-2-one (CAS 324763-46-4)
- 1-Methyl-1H-benzo[d]imidazole-6-boronic Acid Pinacol Ester (CAS 1107627-01-9)
- 2’-(Trifluoromethyl)biphenyl-4-carboxylic Acid (CAS 198205-79-7)
- Semaglutide impurity 36 (CAS CATO-C4X-222636)
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