17-Hydroxy-Methylprednisolone Impurity E Derivative CAS 167997-11-7
| CAS No. | 167997-11-7 |
| Molecular Formula | C21H28O5 |
| Molecular Weight | 360.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, 17-Hydroxy-Methylprednisolone Impurity E Derivative (CAS 167997-11-7, C21H28O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, 17-Hydroxy-Methylprednisolone Impurity E Derivative (C21H28O5) contains a flavonoid core, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 360.44 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H28O5 |
| Molecular Weight | 360.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
Related Hydroxy Standards
- 20(R)-Hydroxy Prednisone (CAS 600-92-0)
- 20-Hydroxy Prednisone (Mixture of Diastereomers) (CAS 2899-94-7)
- 1286878-19-0 rac 4-Hydroxy-7-methoxy-4-(4-benzyloxyphenyl)-1,2,3,4-tetrahydronaphthalene (CAS 1286878-19-0)
- 1-(3-Hydroxy-5-(thiophen-2-yl)phenyl)-3-(naphthalen-2-yl)urea (CAS 1680196-54-6)
- 4-Hydroxy-1-methyl-N-(4-methylphenyl)-2,2-dioxo-1,2-dihydro-2lambda~6~,1-benzothiazine-3-carbothioamide (CAS 477860-32-5)
- 4-Hydroxy-3-(3'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile (CAS 844499-72-5)
- 4-Hydroxy-3-(4'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile (CAS 844499-96-3)
- 4-Hydroxy-N-(7-methyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]oxazepin-2-yl)benzenecarboxamide (CAS 866152-19-4)
Recommended Standards
- Prednisolone EP Impurity F (CAS 600-90-8)
- Cortisone (CAS 53-06-5)
- Prednisolone Impurity 43 (CAS 905-52-2)
- Aldosterone (CAS 52-39-1)
- Vonoprazan Impurity 163 (CAS CATO-C4X-1020163)
- Etoricoxib impurity 69 (CAS 300355-18-4)
- Pramipexole Impurity 17 (CAS 104617-51-8)
- 5-Chloro-3-(2-methoxypropan-2-yl)-1,2,4-thiadiazole (CAS 1433887-48-9)
- 5,7-Dibromo-2-methylquinolin-8-ol (CAS 15599-52-7)
- Ozanimod Impurity 27 (CAS CATO-C4X-290227)
- 5-Bromo-2-butoxybenzaldehyde 515148-88-6 C11H13BrO2 V6334 (CAS 515148-88-6)
- 2-Ethoxy-4-formylphenyl 4-methoxybenzoate (CAS 443729-96-2)
- Spiro[chromane-2,3'-thietan]-4-one 1',1'-dioxide (CAS 1823777-05-4)
- Atrial Natriuretic Polypeptide (4-28), human (CAS 95896-08-5)
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