Apixaban Impurity 175 CAS 1686149-80-3
| CAS No. | 1686149-80-3 |
| Molecular Formula | C28H30N4O5 |
| Molecular Weight | 502.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Apixaban Impurity 175.
As a process- or degradation-related impurity, Apixaban Impurity 175 (CAS 1686149-80-3, C28H30N4O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Apixaban Impurity 175 (C28H30N4O5) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H30N4O5 |
| Molecular Weight | 502.56 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Nitrogen Atoms | 4 |
Related Apixaban Standards
- Apixaban Impurity 152 (CAS CATO-C4X-1088152)
- Apixaban Impurity 176 (CAS 2098457-95-3)
- Apixaban Impurity 61 (CAS CATO-C4X-108861)
- Apixaban Impurity 139 (CAS CATO-C4X-1088139)
- Apixaban Impurity 51 (CAS CATO-C4X-108851)
- Apixaban Impurity 134 (CAS CATO-C4X-1088134)
- Apixaban Impurity 132 (CAS 3094994-84-7)
- Apixaban Impurity 135 (CAS CATO-C4X-1088135)
Recommended Standards
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- Barloxavir impurity 90 (CAS CATO-C4X-210890)
- Dolutegravir Impurity 45 (CAS 2244245-33-6)
- Tafluprost impurity 23 (CAS CATO-C4X-216323)
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- 6,6'-Dimethyl-[1,1'-biphenyl]-2,2'-diol (CAS 32750-01-9)
- Allo-D-Ile27-Tirzepatide (CAS CATO-CPTD788961)
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