Dolutegravir Impurity 45 CAS 2244245-33-6
| CAS No. | 2244245-33-6 |
| Molecular Formula | C21H22FN3O5 |
| Molecular Weight | 415.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dolutegravir Impurity 45 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Dolutegravir Impurity 45 (CAS 2244245-33-6) is a certified pharmaceutical impurity reference standard with the molecular formula C21H22FN3O5 and a molecular weight of 415.41 g/mol.
Dolutegravir Impurity 45 (C21H22FN3O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Dolutegravir Impurity 45 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H22FN3O5 |
| Molecular Weight | 415.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Dolutegravir Standards
- Dolutegravir Impurity 49 (CAS CATO-C4X-162049)
- Dolutegravir Impurity 59 (CAS 2244245-36-9)
- Dolutegravir Impurity 36 (CAS CATO-C4X-162036)
- Dolutegravir (CAS 1051375-16-6)
- Dolutegravir Impurity 1 (CAS 1357289-29-2)
- Dolutegravir Impurity 11 (CAS 1973402-05-9)
- Dolutegravir Impurity 2 (CAS 1309560-49-3)
- Dolutegravir Impurity 4 (CAS 1357289-37-2)
Recommended Standards
- Moxifloxacin Impurity 29 (CAS 1395056-41-3)
- Moxifloxacin impurity 195 (CAS 1620445-17-1)
- Moxifloxacin Impurity 193 (CAS CATO-C4X-1074193)
- Ammoxetine Impurity 7 (CAS CATO-C4X-33577)
- Nicergoline EP Impurity G (CAS 57935-65-6)
- Efavirenz Impurity 11 (CAS CATO-C4X-162711)
- Lacosamide Impurity 29 (CAS 86123-95-7)
- Palbociclib Impurity 157 (CAS CATO-C4X-1125157)
- Valaciclovir Impurity 35 (CAS 21691-44-1)
- 5-(Isoxazol-5-yl)furan-2-carboxylic acid (CAS 1399654-32-0)
- 5-Chloro-N-ethyl-2-methoxyaniline (CAS 1019609-60-9)
- 2-(4-Bromophenoxy)ethanimidamide hydrochloride (CAS 67386-39-4)
- Methyl 2-chloro-5-propylthiazole-4-carboxylate (CAS 1951441-37-4)
- D-[Arg]30-Semaglutide (CAS CATO-C4X-222653)
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