Apixaban Impurity 176 CAS 2098457-95-3
| CAS No. | 2098457-95-3 |
| Molecular Formula | C28H30N4O5 |
| Molecular Weight | 502.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Apixaban Impurity 176 (CAS 2098457-95-3, C28H30N4O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Apixaban Impurity 176 (C28H30N4O5) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H30N4O5 |
| Molecular Weight | 502.56 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Nitrogen Atoms | 4 |
Related Apixaban Standards
- Apixaban Impurity 152 (CAS CATO-C4X-1088152)
- Apixaban Impurity 175 (CAS 1686149-80-3)
- Apixaban Impurity 61 (CAS CATO-C4X-108861)
- Apixaban Impurity 139 (CAS CATO-C4X-1088139)
- Apixaban Impurity 51 (CAS CATO-C4X-108851)
- Apixaban Impurity 134 (CAS CATO-C4X-1088134)
- Apixaban Impurity 132 (CAS 3094994-84-7)
- Apixaban Impurity 135 (CAS CATO-C4X-1088135)
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