Posaconazole Impurity 175 CAS 169265-99-0
| CAS No. | 169265-99-0 |
| Molecular Formula | C12H15FO2 |
| Molecular Weight | 210.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Posaconazole Impurity 175 (CAS 169265-99-0, C12H15FO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C12H15FO2, Posaconazole Impurity 175 contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 210.24 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Posaconazole Impurity 175 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H15FO2 |
| Molecular Weight | 210.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Halogen Content | F-containing |
Related Posaconazole Standards
- Posaconazole Impurity 174 (CAS 2169241-14-7)
- Posaconazole Impurity 164 (CAS CATO-C4X-1208164)
- Posaconazole Impurity 112 (CAS 110931-77-6)
- Posaconazole Impurity 66 (CAS 1428118-25-5)
- Posaconazole Impurity 119 (CAS 2243786-03-8)
- Posaconazole impurity 219 (CAS CATO-C4X-1208219)
- Posaconazole Impurity 262(R/S Mixture) (CAS CATO-C4X-1208262)
- Posaconazole Impurity 86 (CAS 170985-84-9)
Recommended Standards
- DL-Indole-3-lactic Acid-d5 (CAS 2470130-19-7)
- 2-((2-fluorobenzyl)oxy)tetrahydro-2H-pyran (CAS CATO-C3D-262179)
- 1-(4-Amino-2-fluorophenyl)piperidin-3-ol (CAS 1002726-80-8)
- tert-Butyl 3-fluoro-4-methylbenzoate (CAS 866625-11-8)
- Methyl aminolevulinate Impurity 6 (CAS CATO-C4X-29936)
- Iomeprol Impurity 9 (CAS CATO-C4X-18209)
- Itraconazole Impurity 14(and enantiomer) (CAS 67914-85-6)
- 1-(tert-Butoxycarbonyl)-3,5,5-trifluoropiperidine-3-carboxylic acid (CAS 1823865-48-0)
- (R)-Ethyl 2-amino-2-cyclohexylacetate hydrochloride (CAS 35051-64-0)
- Z-Gly-Gly-OH (CAS 2566-19-0)
- tert-Butyl (S)-4-acetyl-2,2-dimethyloxazolidine-3-carboxylate (CAS 785828-28-6)
- (2E)-3-[(6-Chloro-3-pyridinyl)methyl]-2-(nitroimino)-4-imidazolidinol DISCONTINUED, same as W498200 (CAS 1115248-02-6)
- 2-(5-Bromofuran-2-yl)ethan-1-ol (CAS 1339393-03-1)
- Semaglutide impurity 55 (CAS CATO-C4X-222655)
Why CATO?
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