Itraconazole Impurity 14(and enantiomer) CAS 67914-85-6
| CAS No. | 67914-85-6 |
| Molecular Formula | 2*C13H13Cl2N3O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Itraconazole Impurity 14(and enantiomer) is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Itraconazole Impurity 14(and enantiomer) (CAS 67914-85-6) is a certified pharmaceutical impurity reference standard with the molecular formula C13H13Cl2N3O3 and a molecular weight of 330.17 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Itraconazole Impurity 14(and enantiomer) is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 330.17 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Itraconazole Impurity 14(and enantiomer) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | 2*C13H13Cl2N3O3 |
| Molecular Weight | 330.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Itraconazole Standards
- Itraconazole Impurity 44 (CAS 103661-14-9)
- Itraconazole Impurity 41 (CAS 106461-41-0)
- Itraconazole Impurity 93 (CAS 110762-98-6)
- Itraconazole 2-Oxo Metabolite (CAS 112560-33-5)
- Itraconazole Impurity 38 (CAS 115897-54-6)
- Itraconazole N-Formyl-Ethlene Impurity (CAS 1199350-00-9)
- Itraconazole Impurity 73 (CAS 1199350-02-1)
- Itraconazole-d5(major) (CAS 1217510-38-7)
Recommended Standards
- Thiotepa Impurity 3 Sodium Salt (CAS 14056-57-6 (free acid))
- Josamycin EP Impurity K (CAS 18361-48-3)
- LCZ-696 Impurity 63 (CAS CATO-C4X-169663)
- 3-Chloro-6,7,8,9-tetrahydrobenzo[g]cinnolin-4-ol (CAS 858507-58-1)
- 3-Chloro-N-hydroxypyrazine-2-carboximidamide (CAS 175203-31-3)
- 5-(2-Fluorobenzyl)-1-(4-fluorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (CAS 841211-13-0)
- carbamic acid, [2-oxo-2-(phenylamino)ethyl]-, 1,1-dimethylethyl ester (CAS 27904-92-3)
- n'-(Benzenesulfonyl)-1,3-dioxaindane-5-carbohydrazide (CAS 406190-94-1)
- N-(1-Benzyl-3-cyano-4,5-diphenyl-1H-pyrrol-2-yl)-4-methyl-N-(4-methylbenzenesulfonyl)benzene-1-sulfonamide (CAS 477887-18-6)
- Peptide T (CAS 106362-32-7)
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