Guaifenesin EP Impurity D CAS 16929-60-5
| CAS No. | 16929-60-5 |
| Molecular Formula | C17H20O5 |
| Molecular Weight | 304.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Guaifenesin EP Impurity D (CAS 16929-60-5, C17H20O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Guaifenesin EP Impurity D (C17H20O5) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C17H20O5 |
| Molecular Weight | 304.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
Related Guaifenesin Standards
- Guaifenesin Glucose Adduct 1 (CAS CATO-C4X-129410)
- Guaifenesin Glucose Adduct 2 (CAS CATO-C4X-129411)
- Guaifenesin Fructose Adduct 3 (CAS CATO-C4X-129412)
- Guaifenesin Fructose Adduct 4 (CAS CATO-C4X-129413)
- Guaifenesin EP Impurity C (CAS 1797132-23-0)
- Guaifenesin Impurity 5 (CAS 2049-21-0)
- Guaifenesin Metabolite (Glyceryl Guaiacolate Metabolite) (CAS 13057-65-3)
- Guaifenesin-Glyceryl-<SUP>13</SUP>C<SUB>3</SUB> (CAS 1173019-31-2)
Recommended Standards
- Trimethoprim EP Impurity G (CAS 78025-68-0)
- Avibactam impurity 107 (CAS CATO-C4X-1348107)
- Trimethoprim Impurity 12 (CAS 92653-78-6)
- Avibactam Impurity 21 (CAS 1416134-63-8)
- Ramosetron Impurity 7 (CAS CATO-C4X-11827)
- Levetiracetam Impurity 48 (CAS 24032-51-7)
- Lenvatinib Impurity 174 (CAS CATO-C4X-1140174)
- 4-(4-Chlorophenoxy)piperidine hydrochloride (CAS 63843-53-8)
- 2-Amino-5-formylnicotinonitrile (CAS 1211525-18-6)
- Loperamide Impurity 8 HCl (CAS CATO-C4X-17888)
- 3'-Fluoro-[1,1'-biphenyl]-2-amine (CAS 2264-92-8)
- 3-(4-Chlorophenyl)-2-(pyrrolidin-1-yl)quinoline (CAS 339102-80-6)
- Methyl 2,6-bis(bromomethyl)isonicotinate (CAS 381224-18-6)
- Acetyl Tripeptide-1 (CAS 350595-76-5)
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