Guaifenesin Impurity 5 CAS 2049-21-0
| CAS No. | 2049-21-0 |
| Molecular Formula | C11H12O5 |
| Molecular Weight | 224.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Guaifenesin Impurity 5 (CAS 2049-21-0) is a certified pharmaceutical impurity reference standard with the molecular formula C11H12O5 and a molecular weight of 224.21 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system, Guaifenesin Impurity 5 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 224.21 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Guaifenesin Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H12O5 |
| Molecular Weight | 224.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Guaifenesin Standards
- Guaifenesin Metabolite (Glyceryl Guaiacolate Metabolite) (CAS 13057-65-3)
- Guaifenesin-Glyceryl-<SUP>13</SUP>C<SUB>3</SUB> (CAS 1173019-31-2)
- Guaifenesin EP Impurity B-D4 (CAS 114609-65-3)
- Guaifenesin-d3 (CAS 1189924-85-3)
- Guaifenesin Impurity 1 (CAS 61248-75-7)
- Guaifenesin EP Impurity B (CAS 14007-09-1)
- Guaifenesin EP Impurity D (CAS 16929-60-5)
- Guaifenesin Impurity 7 (CAS 120-80-9)
Recommended Standards
- Repaglinide EP Impurity A (CAS 220438-80-2)
- Rivastigmine Impurity 14 (CAS 1346242-31-6)
- Gefitinib Impurity 73 (CAS CATO-C4X-111773)
- Rivastigmine Impurity 19 (CAS CATO-C4X-138419)
- Calcipotriol Impurity A (CAS 126860-84-2)
- Caspofungin impurity 59 (CAS CATO-C4X-157559)
- Methotrexate Impurity 67 (CAS CATO-C4X-115467)
- 3-(Cbz-Amino)-1,5-dimethylpyrazole (CAS 1445322-58-6)
- tert-Butyl 3,6,9,12,15,18,21-heptaoxadotriacont-31-enoate (CAS 887353-83-5)
- Ethyl 5-amino-1-(2-hydroxyethyl)-3-methyl-1H-pyrazole-4-carboxylate (CAS 1789723-06-3)
- 2-[N-[2-(Fmoc-amino)ethyl]-2-[4-[[(benzhydryloxy)carbonyl]amino]-2-oxopyrimidin-1(2H)-yl]acetamido]acetic Acid (CAS 186046-81-1)
- Asimadoline (CAS 153205-46-0)
- Methyl 4-(prop-1-en-2-yl)cyclohex-1-ene-1-carboxylate (CAS 54298-90-7)
- Semaglutide impurity 215 (CAS CATO-C4X-2226215)
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