Trimethoprim Impurity 12 CAS 92653-78-6
| CAS No. | 92653-78-6 |
| Molecular Formula | C15H20N4O3 |
| Molecular Weight | 304.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Trimethoprim Impurity 12 (CAS 92653-78-6), a pharmacopoeial impurity reference standard (molecular formula C15H20N4O3, MW 304.34 g/mol) used for the identification and quantification of trace impurities in APIs.
Trimethoprim Impurity 12 (C15H20N4O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H20N4O3 |
| Molecular Weight | 304.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1983 |
| Nitrogen Atoms | 4 |
Related Trimethoprim Standards
- Trimethoprim EP Impurity A (CAS 213745-86-9)
- Trimethoprim EP Impurity G (CAS 78025-68-0)
- Trimethoprim EP Impurity B (CAS 30806-86-1)
- Trimethoprim N-Oxide 1 (CAS 27653-68-5)
- Trimethoprim N-Oxide 3 (CAS 27653-67-4)
- Trimethoprim EP Impurity C (CAS 29606-06-2)
- Trimethoprim-d9 (CAS 1189460-62-5)
- Trimethoprim-d3 (CAS 1189923-38-3)
Recommended Standards
- Ilaprazole Impurity 14 (CAS CATO-C4X-113014)
- Guaifenesin EP Impurity D (CAS 16929-60-5)
- Apixaban Impurity 165 (CAS CATO-C4X-1088165)
- Avibactam impurity 107 (CAS CATO-C4X-1348107)
- Tetrabenazine Impurity 26-D9 (CAS CATO-C4X-274826)
- Montelukast Impurity 8 (CAS CATO-C4X-10318)
- Febuxostat t-Butyl Ether Acid Impurity (CAS 2418591-43-0)
- 4-(Pyrid-2-yloxy)benzoic acid (CAS 51363-00-9)
- 2-((1,3,4-Thiadiazol-2-yl)thio)-1-(3-bromothiophen-2-yl)ethan-1-one (CAS 1156280-33-9)
- N,N-bis(2-cyanoethyl)-2,2,2-trifluoroacetamide (CAS 434-46-8)
- Empagliflozin impurity 246 (CAS CATO-C4X-1065246)
- 7-Chloro-4-methyl-2-oxo-3,4-dihydro-2H-pyrido-[1,2-a]pyrimidine-4-carboxylic acid (CAS 957503-19-4)
- 2-((Tert-butoxycarbonyl)amino)-3-(4-methyl-1H-indol-3-yl)propanoic acid (CAS 1219232-56-0)
- Semaglutide Impurity 131 (CAS 2618647-80-4)
Why CATO?
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