rac Nebivolol Hydrochloride CAS 169293-50-9
| CAS No. | 169293-50-9 |
| Molecular Formula | C22H25F2NO4 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
rac Nebivolol Hydrochloride (CAS 169293-50-9) is a high-purity analytical reference standard with the molecular formula C22H25F2NO4HCl and a molecular weight of 441.90 g/mol.
The molecular framework of rac Nebivolol Hydrochloride (C22H25F2NO4HCl) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H25F2NO4 HCl |
| Molecular Weight | 441.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related rac Standards
- Nebivolol Impurity 66 (CAS 1017878-67-9)
- Nebivolol Impurity 15 (CAS 1029684-20-5)
- Nebivolol Impurity 20 (CAS 105300-40-1)
- Nebivolol Impurity 28 (CAS 112068-01-6)
- D-Nebivolol (SR,RR) (CAS 118457-15-1)
- L-Nebivolol (RS,SS) (CAS 118457-16-2)
- Nebivolol Hydrochloride EP Impurity B (CAS 119365-23-0)
- Nebivolol Impurity 32（SS,RS）or（SR,SS） (CAS 119365-25-2)
Recommended Standards
- 2-chloro-6-methoxybenzene-1-sulfonyl chloride (CAS 491850-54-5)
- 7-Bromo-6-fluorobenzo[b]thiophene-2-carboxylic acid (CAS 1781503-02-3)
- (2-azidoethyl)[(3-fluorophenyl)methyl]methylamine (CAS 1251380-65-0)
- 3-Fluoro-4-methoxyphenethyl acetate (CAS 1443351-05-0)
- (3S,4S)-1-(tert-butoxycarbonyl)-4-(ethoxycarbonyl)pyrrolidine-3-carboxylic acid (CAS 595547-21-0)
- (1-Methyl-1H-pyrrole-3,4-diyl)dimethanol (CAS 73529-27-8)
- Ethyl 2-(3-hydroxyphenyl)-4-methylthiazole-5-carboxylate (CAS 209538-87-4)
- 5-Chloro-3-ethoxybenzofuran-2-carboxylic acid (CAS 1710661-34-9)
- 4-(2-Bromophenyl)butan-2-one (CAS 3506-68-1)
- Peptide WE-14 (CAS 115136-18-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com