Nebivolol Impurity 66 CAS 1017878-67-9
| CAS No. | 1017878-67-9 |
| Molecular Formula | C11H12ClFO2 |
| Molecular Weight | 230.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Nebivolol Impurity 66 (CAS 1017878-67-9) is a certified pharmaceutical impurity reference standard with the molecular formula C11H12ClFO2 and a molecular weight of 230.66 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, Nebivolol Impurity 66 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 230.66 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nebivolol Impurity 66 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H12ClFO2 |
| Molecular Weight | 230.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Cl-containing |
Related Nebivolol Standards
- Nebivolol Impurity 72 (CAS CATO-C4X-196872)
- Nebivolol Impurity 73 (CAS CATO-C4X-196873)
- Nebivolol Impurity 23 (CAS CATO-C4X-196823)
- Nebivolol Impurity 24 (CAS CATO-C4X-196824)
- Nebivolol Impurity 27 (CAS CATO-C4X-196827)
- Nebivolol Impurity 68 (CAS CATO-C4X-196868)
- Nebivolol Impurity 71 (CAS CATO-C4X-196871)
- Nebivolol Impurity 10 (CAS CATO-C4X-196810)
Recommended Standards
- tert-Butyl 2-chloro-4-fluorobenzoate (CAS 911314-43-7)
- t-Butyl 4-chloro-2-fluorobenzoate (CAS 941294-14-0)
- Methyl 2-chloro-4-(2-fluoropropan-2-yl)benzoate (CAS 2114269-56-4)
- Imidazo[1,2-a]pyridin-2-ylmethanesulfonyl chloride (CAS 1016724-48-3)
- Avatrombopag Impurity 59 (CAS 2948773-23-5)
- Biperiden EP Impurity A (CAS CATO-C4X-31651)
- Brivaracetam Impurity 191 (CAS CATO-C4X-2007191)
- 4-Chloro-5-hydrazinyl-2,3-dihydropyridazin-3-one (CAS 6959-56-4)
- 2-(3-Chloro-4-isobutoxyphenyl)ethanol (CAS 1443348-58-0)
- 1-Butyrylpyrrolidine-3-carboxylic acid (CAS 1245614-92-9)
- TFB-TBOA (CAS 480439-73-4)
- 1-Benzoyl-4-benzylpiperidine-4-carboxylic acid (CAS 136080-23-4)
- N-(1H-1,3-Benzimidazol-2-yl)benzenesulfonamide (CAS 13068-57-0)
- C-Type Natriuretic Peptide (32-53) (human, porcine, rat) (CAS 127869-51-6)
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