Nebivolol Impurity 28 CAS 112068-01-6
| CAS No. | 112068-01-6 |
| Molecular Formula | C17H19NO |
| Molecular Weight | 253.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Nebivolol Impurity 28 (CAS 112068-01-6, C17H19NO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C17H19NO, Nebivolol Impurity 28 contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 253.34 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C17H19NO |
| Molecular Weight | 253.34 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 1 |
Related Nebivolol Standards
- Nebivolol Impurity 104 (CAS 1345202-52-9)
- Nebivolol Impurity 49 (CAS 797054-16-1)
- Nebivolol Impurity 44 (CAS 18867-45-3)
- Nebivolol Impurity 64 (CAS CATO-C4X-196864)
- Nebivolol Impurity 65 (CAS CATO-C4X-196865)
- Nebivolol Impurity 69 (CAS CATO-C4X-196869)
- Nebivolol Impurity 66 (CAS 1017878-67-9)
- Nebivolol Impurity 72 (CAS CATO-C4X-196872)
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