8-Methyl-4-(trifluoromethyl)quinolin-2(1H)-one CAS 1701-23-1
| CAS No. | 1701-23-1 |
| Molecular Formula | C11H8F3NO |
| Molecular Weight | 227.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 8-Methyl-4-(trifluoromethyl)quinolin-2(1H)-one (CAS 1701-23-1), a certified reference material (molecular formula C11H8F3NO, MW 227.18 g/mol) for analytical method development and quality control.
The molecular framework of 8-Methyl-4-(trifluoromethyl)quinolin-2(1H)-one (C11H8F3NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 8-Methyl-4-(trifluoromethyl)quinolin-2(1H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H8F3NO |
| Molecular Weight | 227.18 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Methyl Standards
- 1-Methyl-7-(trifluoromethyl)quinolin-4(1H)-one (CAS 108494-53-7)
- (4-(Trifluoromethyl)quinolin-2-yl)methanol (CAS 1116339-56-0)
- 1-Methyl-8-(trifluoromethyl)quinolin-4(1H)-one (CAS 1209284-64-9)
- 6-Methyl-2-(trifluoromethyl)quinolin-4(1H)-one (CAS 123638-04-0)
- β-(Trifluoromethyl)-4-morpholinepropanoic acid (CAS 1343857-33-9)
- 1-(6-(Trifluoromethyl)-1H-indol-4-yl)ethanone (CAS 1352897-41-6)
- 5'-(Trifluoromethyl)-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-2'-one (CAS 1360898-86-7)
- 7'-(Trifluoromethyl)spiro[cyclopropane-1,3'-indolin]-2'-one (CAS 1360931-90-3)
Recommended Standards
- 4-Hydroxy-6-methyl-2-(trifluoromethyl)quinoline (CAS 1701-20-8)
- 1-[4-(Trifluoromethoxy)phenyl]cyclopropanecarbonitrile (CAS 173859-39-7)
- 8-Methyl-2-(trifluoromethyl)quinolin-4-ol (CAS 1701-19-5)
- 4'-(Trifluoromethyl)spiro[cyclopropane-1,3'-indolin]-2'-one (CAS 1822816-46-5)
- (7-Methylnaphthalen-2-yl)boronic acid (CAS 2125969-38-0)
- Methyl 2,6-difluoro-4-vinylbenzoate (CAS 1431948-81-0)
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