Leflunomide Impurity 18 CAS 17153-20-7
| CAS No. | 17153-20-7 |
| Molecular Formula | C5H5NO3 |
| Molecular Weight | 127.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Leflunomide Impurity 18 (CAS 17153-20-7, C5H5NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Leflunomide Impurity 18 (C5H5NO3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Leflunomide Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H5NO3 |
| Molecular Weight | 127.10 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1961 |
| Nitrogen Atoms | 1 |
Related Leflunomide Standards
- Leflunomide Impurity 3 (CAS 2772495-33-5)
- Leflunomide Impurity 7 (CAS 88511-40-4)
- Leflunomide EP Impurity D (CAS 42831-50-5)
- Leflunomide Impurity 15 (CAS 4637-24-5)
- Leflunomide Impurity 17 (CAS 67305-24-2)
- Leflunomide Impurity 19 (CAS 51135-73-0)
- Leflunomide EP Impurity A (CAS 455-14-1)
- Leflunomide Impurity 14 (CAS 51145-57-4)
Recommended Standards
- Cefazolin Impurity 53 (CAS 26476-16-4)
- Ribavirin Impurity 51 (CAS 4928-88-5)
- Molnupiravir Impurity 17 (CAS 20555-88-8)
- Metronidazole Impurity 24 (CAS 3034-42-2)
- Penfluridol Impurity 4 (CAS CATO-C4X-35384)
- Trelagliptin Impurity 69 (CAS CATO-C4X-104669)
- Cefaclor Impurity 9 (CAS 6485-67-2)
- N-(2-Hydroxy-3-sulfopropyl)-3,5-dimethoxyaniline Sodium Salt [for Biochemical Research] (CAS 82692-88-4)
- 3-Phenyl-2-(p-tolyl)-2H-isoindol-1-amine (CAS 106697-64-7)
- 1-(2,5-Dimethylphenyl)-5-thioxopyrrolidin-2-one (CAS 634151-19-2)
- 1-Iodooctane-d17 (stabilized with copper) (CAS 340256-37-3)
- Ethyl 5-hydroxy-2-phenylbenzofuran-3-carboxylate (CAS 4610-75-7)
- 7-(Hydroxymethyl)-2-naphthoic acid (CAS 162514-07-0)
- Semaglutide impurity 68 (CAS CATO-C4X-222668)
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