Leflunomide Impurity 14 CAS 51145-57-4
| CAS No. | 51145-57-4 |
| Molecular Formula | C9H15NO3 |
| Molecular Weight | 185.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Leflunomide Impurity 14 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Leflunomide Impurity 14 (CAS 51145-57-4, C9H15NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Leflunomide Impurity 14 (C9H15NO3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C9H15NO3 |
| Molecular Weight | 185.22 g/mol |
| Appearance | White to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1971 |
| Nitrogen Atoms | 1 |
Related Leflunomide Standards
- Leflunomide EP Impurity A (CAS 455-14-1)
- Leflunomide Impurity 19 (CAS 51135-73-0)
- Leflunomide Impurity 25 (CAS CATO-C4X-167325)
- Leflunomide EP Impurity G (CAS 724429-16-7)
- Leflunomide Impurity 17 (CAS 67305-24-2)
- Leflunomide Impurity 21 (CAS 202057-74-7)
- Leflunomide EP Impurity H (CAS 24522-30-3)
- Leflunomide Impurity 3 (CAS 2772495-33-5)
Recommended Standards
- Nimesulide EP Impurity C (CAS 2688-84-8)
- Tranexamic Acid Impurity 6 (CAS CATO-C4X-17716)
- Naphazoline Impurity 6 (CAS 36660-46-5)
- Tranexamic Acid EP Impurity F (CAS 1599413-49-6)
- Prilocaine impurity 38 (CAS 2729898-89-7)
- Ibuprofen Impurity 63 (CAS CATO-C4X-108263)
- Tipiracil Impurity 5 (CAS CATO-C4X-10055)
- Ethyl 5-chloro-4-methyl-2-nitrobenzoate (CAS 1805129-59-2)
- 1-(5-Bromo-3-fluoro-2-pyridyl)piperazine (CAS 1141669-85-3)
- 2-(Pyridin-3-yl)-5-(pyrrolidin-2-yl)-1,3,4-oxadiazole (CAS 1181561-29-4)
- 4-{[4-(tert-Butyl)benzyl]oxy}piperidine 4020AF 946681-43-2 C16H25NO (CAS 946681-43-2)
- (2R,3S)-2-(4-(cyclopentylamino)phenyl)-1-(2-fluoro-6-methylbenzoyl)piperidine-3-carboxylic acid (CAS 1346623-11-7)
- (4-(Difluoromethyl)-3-nitropyridin-2-yl)methanol (CAS 1805298-83-2)
- Cycloaspeptide D (CAS 691363-62-9)
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