Leflunomide Impurity 17 CAS 67305-24-2
| CAS No. | 67305-24-2 |
| Molecular Formula | C5H4ClNO2 |
| Molecular Weight | 145.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Leflunomide Impurity 17 (CAS 67305-24-2), a pharmacopoeial impurity reference standard (molecular formula C5H4ClNO2, MW 145.54 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Leflunomide Impurity 17 (C5H4ClNO2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 145.54 g/mol, it falls into the low-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Leflunomide Impurity 17 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H4ClNO2 |
| Molecular Weight | 145.54 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Leflunomide Standards
- Leflunomide Impurity 19 (CAS 51135-73-0)
- Leflunomide EP Impurity A (CAS 455-14-1)
- Leflunomide Impurity 3 (CAS 2772495-33-5)
- Leflunomide Impurity 7 (CAS 88511-40-4)
- Leflunomide Impurity 18 (CAS 17153-20-7)
- Leflunomide EP Impurity D (CAS 42831-50-5)
- Leflunomide Impurity 15 (CAS 4637-24-5)
- Leflunomide Impurity 14 (CAS 51145-57-4)
Recommended Standards
- Gimeracil (CAS 103766-25-2)
- 2-Chloro-4-methoxy-1,3,5-triazine (CAS 112667-87-5)
- 914637-76-6 5-Methyl-1,3-oxazole-4-carbonyl chloride MFCD08056322 (CAS 914637-76-6)
- 3-Chloro-5-methoxy-1,2,4-triazine (CAS 1249811-78-6)
- Ceftolozane Impurity 10 (CAS CATO-C4X-240610)
- Sorafenib Impurity 11 (CAS 1129683-88-0)
- Lenvatinib Impurity 63 (CAS 2380197-89-5)
- (2S)-3-methoxy-2-(methylamino)propanamide hydrochloride (CAS 1807941-79-2)
- 4-Isopropoxy-3-nitrobenzylamine (CAS 1152559-53-9)
- Diethyl 2-(amino(propylamino)methylene)malonate (CAS 40657-67-8)
- 2-Bromo-4-methylbenzo[d]thiazole (CAS 73443-76-2)
- 1-(2-Amino-5-methoxy-4-(trifluoromethyl)phenyl)ethan-1-one (CAS 1823784-04-8)
- N'-(3-Ethoxy-4-hydroxybenzylidene)pyrazine-2-carbohydrazide (CAS 304908-54-1)
- Acetyl Dipeptide-1 (CAS 196604-48-5)
Why CATO?
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