Tadalafil Impurity 134 CAS 171596-43-3
| CAS No. | 171596-43-3 |
| Molecular Formula | C20H18N2O4 |
| Molecular Weight | 350.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Tadalafil Impurity 134 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Tadalafil Impurity 134 (CAS 171596-43-3, C20H18N2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Tadalafil Impurity 134 (C20H18N2O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C20H18N2O4 |
| Molecular Weight | 350.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2006 |
| Nitrogen Atoms | 2 |
Related Tadalafil Standards
- Tadalafil Impurity 133 (CAS 171596-44-4)
- Tadalafil Impurity 15 (CAS 171596-42-2)
- Tadalafil Impurity 178 (CAS CATO-C4X-1087178)
- Tadalafil Impurity 36 (CAS CATO-C4X-108736)
- Tadalafil Impurity 74 (CAS 171596-41-1)
- Tadalafil Impurity 83 (CAS CATO-C4X-108783)
- Tadalafil Impurity 21 (CAS 951661-85-1)
- Tadalafil Impurity 23 (CAS 951661-82-8)
Recommended Standards
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- Axitinib Impurity 18 (CAS CATO-C4X-107118)
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- Ozagrel Impurity 23 (CAS 78712-44-4)
- Ezetimibe Impurity 25 (CAS 404874-94-8)
- Lifitegrast Impurity 84 (CAS CATO-C4X-240984)
- 3-[methyl(propan-2-yl)sulfamoyl]benzoic acid (CAS 747411-03-6)
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- 2-Nitrophenylethyl bromide (CAS 16793-89-8)
- 9H-Indeno[1,2-b]pyrazin-9-one (CAS 93194-44-6)
- 4-n-Pentyloxybenzaldehyde-α-d1 (CAS 342611-09-0)
- Tert-butyl 4-(5-methyl-1,2,4-oxadiazol-3-yl)piperidine-1-carboxylate (CAS 280110-66-9)
- Semaglutide impurity 96 (CAS CATO-C4X-222696)
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