Tretinoin Impurity 7 CAS 173326-85-7
| CAS No. | 173326-85-7 |
| Molecular Formula | C20H28O2 |
| Molecular Weight | 300.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Tretinoin Impurity 7 (CAS 173326-85-7) is a certified pharmaceutical impurity reference standard with the molecular formula C20H28O2 and a molecular weight of 300.44 g/mol.
The molecular framework of Tretinoin Impurity 7 (C20H28O2) is characterized by a steroid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H28O2 |
| Molecular Weight | 300.44 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2006 |
Related Tretinoin Standards
- Tretinoin EP Impurity B (9,13-di-cis-Retinoic Acid) (CAS 5352-74-9)
- Tretinoin Impurity 27 (CAS CATO-C4X-196927)
- Tretinoin EP Impurity C (Isotretinoin EP Impurity C, 11,13-di-cis-Retinoic Acid) (CAS 3555-80-4)
- Tretinoin (CAS 302-79-4)
- Tretinoin-d5 (CAS CATO-C4X-196937)
- 4-Oxo Tretinoin (4-Oxo Retinoic Acid) (CAS 38030-57-8)
- Tretinoin EP Impurity G (CAS 13100-69-1)
- Tretinoin Impurity 12 (CAS 3899-20-5)
Recommended Standards
- Promestriene Impurity 1 (CAS CATO-C4X-22051)
- Epristeride Impurity 4 (CAS CATO-C4X-30084)
- Isotretinoin EP Impurity D (CAS 5300-03-8)
- Methandrostenolone (CAS 72-63-9)
- Bicalutamide Impurity 10 (CAS 367-67-9)
- Rivaroxaban Impurity 105 (CAS CATO-C4X-1090105)
- Etodolac EP Impurity C (Etodolac USP Related Compound A) (CAS 109518-47-0)
- Thiazole-4-carboximidamide Hydrochloride (CAS 23964-52-5)
- 3-Cyclopropoxy-N,6-dimethylpicolinamide (CAS 1243364-50-2)
- 3-(3-fluoro-4-methoxyphenyl)-4-methyl-1H-pyrazole (CAS 1007033-91-1)
- ethyl 7-cyclopropyl-2-phenylpyraZolo[1,5-a]pyrimidine-6-carboxylate (CAS 1245808-03-0)
- N-(6-Ethylbenzo[d]thiazol-2-yl)-N-(pyridin-3-ylmethyl)acetamide (CAS 895026-70-7)
- 2-Methyl-3-((2,4,5-trimethylbenzyl)amino)propanenitrile (CAS 1249360-23-3)
- Peptide YY (3-36) (human) (CAS 123583-37-9)
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