Tretinoin EP Impurity B (9,13-di-cis-Retinoic Acid) CAS 5352-74-9
| CAS No. | 5352-74-9 |
| Molecular Formula | C20H28O2 |
| Molecular Weight | 300.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Tretinoin EP Impurity B (9,13-di-cis-Retinoic Acid) (CAS 5352-74-9, C20H28O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, a hydroxyl group, an ether linkage, Tretinoin EP Impurity B (9,13-di-cis-Retinoic Acid) is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 300.44 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H28O2 |
| Molecular Weight | 300.44 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
Related Tretinoin Standards
- Tretinoin Impurity 27 (CAS CATO-C4X-196927)
- Tretinoin EP Impurity C (Isotretinoin EP Impurity C, 11,13-di-cis-Retinoic Acid) (CAS 3555-80-4)
- Tretinoin Impurity 7 (CAS 173326-85-7)
- Tretinoin (CAS 302-79-4)
- Tretinoin-d5 (CAS CATO-C4X-196937)
- 4-Oxo Tretinoin (4-Oxo Retinoic Acid) (CAS 38030-57-8)
- Tretinoin EP Impurity G (CAS 13100-69-1)
- Tretinoin Impurity 12 (CAS 3899-20-5)
Recommended Standards
- Ropinirole Hydrochloride EP Impurity C (CAS 784110-47-0)
- Isotretinoin EP Impurity F (CAS 68070-35-9)
- Levonorgestrel EP Impurity R (CAS 2322-77-2)
- Isotretinoin EP Impurity D (CAS 5300-03-8)
- Isoflurane EP Impurity A (CAS 33018-78-9)
- Nintedanib Impurity 44 (CAS 3395-80-0)
- Cabozantinib Impurity 16 (CAS 95932-39-1)
- Xylazine Hydrochloride EP Impurity D (CAS 120077-91-0)
- 1-(2-Methylphenyl)cyclopropane-1-carbonitrile (CAS 124276-51-3)
- sec-Butyl 2-bromoacetate (CAS 5205-36-7)
- 8-(2-Methoxyethyl)-8-azabicyclo[3.2.1]octan-3-one (CAS 174486-94-3)
- N-(6-Morpholinopyridin-3-yl)chromane-3-carboxamide (CAS 1197599-82-8)
- N-(3,4-Dimethylphenyl)-2-{[(4-fluorophenyl)sulfonyl]amino}propanamide (CAS 317378-02-2)
- [Ser39-OH] Tirzepatide (CAS CATO-C4X-324041)
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