Metolazone impurity 2 CAS CATO-C4X-29702
| CAS No. | CATO-C4X-29702 |
| Molecular Formula | C16H15ClN4O4S |
| Molecular Weight | 394.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Metolazone impurity 2 (CAS CATO-C4X-29702, C16H15ClN4O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, Metolazone impurity 2 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 394.83 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Metolazone impurity 2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H15ClN4O4S |
| Molecular Weight | 394.83 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Metolazone Standards
Recommended Standards
- N-Nitroso Metolazone (CAS CATO-C4X-29701)
- 2,4-Dimethyl-9H-carbazole (CAS 18992-71-7)
- N-Nitroso Indapamide (CAS CATO-C4X-140044)
- 1-(2-(4-Chlorophenoxy)pyridin-3-yl)-6,7-dimethoxy-3,4-dihydroisoquinoline (CAS 1023554-63-3)
- Lemborexant Impurity 96 (CAS CATO-C4X-304296)
- Apremilast Impurity 103 (CAS 62351-80-8)
- Prasugrel Impurity 34 Maleate (CAS 150322-38-6(free base))
- (2R,3R,4R,5S,6R)-6-(acetoxymethyl)-3-(1,3-dioxoisoindolin-2-yl)tetrahydro-2H-pyran-2,4,5-triyl triacetate (CAS 31505-44-9)
- Benzyl-PEG6-MS (CAS 1262681-32-2)
- Sodium Sorbate (CAS 7757-81-5)
- Ambroxol Impurity 52 (CAS 946122-05-0)
- (5-Hydroxy-1-pentyl-1H-indol-3-yl)-1-naphthalenylmethanone (CAS 1307803-43-5)
- 2-chloro-1-(1-isopropyl-2,5-dimethyl-1H-pyrrol-3-yl)ethanone (CAS 786728-93-6)
- Semaglutide impurity 108 (CAS CATO-C4X-2226108)
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