Irinotecan Impurity 49 CAS 177611-40-4
| CAS No. | 177611-40-4 |
| Molecular Formula | C20H24N2O3 |
| Molecular Weight | 340.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Irinotecan Impurity 49 (CAS 177611-40-4, C20H24N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Irinotecan Impurity 49 (C20H24N2O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C20H24N2O3 |
| Molecular Weight | 340.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2007 |
| Nitrogen Atoms | 2 |
Related Irinotecan Standards
- Irinotecan Impurity 70 (CAS 100286-91-7)
- Irinotecan Impurity 59 (CAS CATO-C4X-166759)
- Irinotecan Hydrochloride Trihydrate EP Impurity B (CAS 19685-09-7)
- Irinotecan Impurity 9 (CAS 80758-83-4)
- Irinotecan EP Impurity F (CAS 78287-27-1)
- Irinotecan Impurity 23 (CAS 1217633-65-2)
- Irinotecan Impurity 8 (CAS 78287-14-6)
- Irinotecan Impurity 56 (CAS 797762-11-9)
Recommended Standards
- Famotidine-13C3 (CAS 1185241-48-8)
- Ticarcillin EP Impurity A (CAS CATO-C4X-17631)
- Fasudil Impurity 26 (CAS 4392-52-3)
- Indobufen Impurity 53 (CAS CATO-C4X-179253)
- Aceclofenac Impurity 16 (CAS CATO-C4X-153116)
- Faropenem Impurity 33 (CAS CATO-C4X-128933)
- Ruxolitinib Impurity N4 Dibenzoyltartaric Acid Salt (CAS 1236033-04-7)
- Methyl (2,2,2-trifluoro-1-phenylethyl)glycinate (CAS 1100246-06-7)
- 1-(2-Aminoethyl)pyrimidin-2(1H)-one dihydrochloride (CAS 2173999-35-2)
- N-[6-(benzyloxy)pyridin-3-yl]sulfamic acid (CAS 1795514-19-0)
- 2-(4-Bromophenyl)pyrimidin-4(1H)-one (CAS 88627-12-7)
- n1-(6,7-Dimethoxy-2-methylquinazolin-4-yl)ethane-1,2-diamine (CAS 1092460-56-4)
- 1-(prop-2-en-1-yl)cyclobutane-1-carbonitrile (CAS 1803570-71-9)
- Semaglutide impurity 268 (CAS CATO-C4X-2226268)
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