Ponatinib Impurity 50 CAS 1781021-72-4
| CAS No. | 1781021-72-4 |
| Molecular Formula | C6H3Br2N3 |
| Molecular Weight | 276.92 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Ponatinib Impurity 50 (C6H3Br2N3) contains a nitrile group, bromine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 276.92 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Ponatinib Impurity 50 (CAS 1781021-72-4, C6H3Br2N3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Ponatinib Impurity 50 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H3Br2N3 |
| Molecular Weight | 276.92 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
Related Ponatinib Standards
- Ponatinib impurity 7 (CAS 1300690-48-5)
- Ponatinib Impurity 51 (CAS 94224-92-7)
- Ponatinib impurity 4 (CAS 694499-26-8)
- Ponatinib Impurity 56 (CAS CATO-C4X-226956)
- Ponatinib Impurity 57 (CAS CATO-C4X-226957)
- Ponatinib Impurity 38 (CAS 2755819-36-2)
- Ponatinib Impurity 52 (CAS 31719-79-6)
- Ponatinib Impurity 30 (CAS CATO-C4X-226930)
Recommended Standards
- 6,8-Dibromoimidazo[1,2-α]pyrazine (CAS 63744-22-9)
- 7-Bromo-3,4-dichloroquinoline (CAS 1021435-01-7)
- 5,8-Dibromoimidazo[1,2-a]pyrazine (CAS 957344-74-0)
- 4-Bromo-5,8-dichloroquinoline (CAS 1070879-38-7)
- Raltitrexed Impurity 5 (CAS 4282-31-9)
- Edoxaban Impurity 142 (CAS CATO-C4X-1063142)
- Elobixibat Impurity 47 (CAS 1907648-74-1)
- 4-(tert-Butyl)-2-chloropyrimidine (CAS 66522-06-3)
- 2-(2-Chloro-5-fluorobenzyl)-4,4-dimethylisoxazolidin-3-one (CAS 81778-10-1)
- Lefamulinum Impurity 45 (CAS CATO-C4X-304745)
- 2-Methylphenethylamine 2-(o-Tolyl)ethylamine 2-(2-methylphenyl)ethan-1-amine 2-o-tolyl-ethylamine 55755-16-3 (CAS 55755-16-3)
- Des-Ser1-Thymalfasin (CAS CATO-C4X-189819)
- 5-Fluoro-6-(trifluoromethyl)pyrimidin-4(3H)-one (CAS 2446509-01-7)
- HA Peptide (CAS 92000-76-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com