Ponatinib Impurity 52 CAS 31719-79-6
| CAS No. | 31719-79-6 |
| Molecular Formula | C8H7IO2 |
| Molecular Weight | 262.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ponatinib Impurity 52.
As a process- or degradation-related impurity, Ponatinib Impurity 52 (CAS 31719-79-6, C8H7IO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ponatinib Impurity 52 (C8H7IO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ponatinib Impurity 52 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H7IO2 |
| Molecular Weight | 262.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | I-containing |
Related Ponatinib Standards
- Ponatinib Impurity 30 (CAS CATO-C4X-226930)
- Ponatinib impurity 4 (CAS 694499-26-8)
- Ponatinib Impurity 51 (CAS 94224-92-7)
- Ponatinib Impurity 50 (CAS 1781021-72-4)
- Ponatinib impurity 7 (CAS 1300690-48-5)
- Ponatinib Impurity 24【Discontinued,See C4X-22692】 (CAS CATO-C4X-226924)
- Ponatinib Impurity 2 (CAS CATO-C4X-22692)
- Ponatinib Impurity 56 (CAS CATO-C4X-226956)
Recommended Standards
- 2-Iodo-5-methylbenzoic acid (CAS 52548-14-8)
- Montelukast Impurity N27 (CAS 610-97-9)
- 4-Iodo-3-methylbenzoic acid (CAS 52107-87-6)
- 6-Iodo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine (CAS 1203499-61-9)
- CAS 1062642-68-5 (CAS 1062642-68-5)
- Brexpiprazole Impurity 99 (CAS CATO-C4X-113199)
- Sunitinib Impurity 44 (CAS 110-72-5)
- 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline hydrochloride (CAS 6268-86-6)
- 5,5-dimethyl-2-(3-oxo-1,3-diphenylpropyl)cyclohexane-1,3-dione (CAS 53852-97-4)
- 3,5,5-Trimethyl-4-(3-oxobutyl)-2-cyclohexen-1-one (CAS 74233-41-3)
- N-((4S,5S)-2-(2-(1H-Imidazol-5-yl)ethyl)-5-methyl-3-oxoisoxazolidin-4-yl)-2,3-dihydroxybenzamide (CAS 160472-93-5)
- 1,2,3,4-Tetrahydro-6-isoquinolin-6-ol Hydrobromide (CAS 59839-23-5)
- 3-(Cyanomethyl)-6-(difluoromethyl)-4-methylpicolinonitrile (CAS 1805429-03-1)
- Liraglutide Impurity 10 TFA Salt (CAS CATO-C4X-199210)
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