Propranolol Impurity 10 CAS 27610-48-6
| CAS No. | 27610-48-6 |
| Molecular Formula | C16H16O4 |
| Molecular Weight | 272.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Propranolol Impurity 10.
CATO supplies Propranolol Impurity 10 (CAS 27610-48-6), a pharmacopoeial impurity reference standard (molecular formula C16H16O4, MW 272.30 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Propranolol Impurity 10 (C16H16O4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H16O4 |
| Molecular Weight | 272.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
Related Propranolol Standards
- Propranolol Impurity 53 (CAS CATO-C4X-151953)
- Propranolol Impurity 58 (CAS CATO-C4X-151958)
- Propranolol Impurity 9 (CAS 4662-18-4)
- Propranolol Impurity 39 (CAS CATO-C4X-151939)
- Rac-Propranolol-d7 (CAS 344298-99-3)
- rac-Propranolol-d7 (CAS 98897-23-5)
- Propranolol Impurity 15 (CAS CATO-C4X-151915)
- (S)-Propranolol, 98% (CAS 4199-09-1)
Recommended Standards
- Ambrisentan Impurity 8 (CAS CATO-C4X-12468)
- Iguratimod impurity 89 (CAS CATO-C4X-182689)
- Ambrisentan Impurity 5 (CAS 178306-51-9)
- Neostigmine Impurity 50 (CAS 16460-28-9)
- Econazole Impurity 26 (CAS 24155-34-8)
- Gadoxetate Impurity 33 (CAS CATO-C4X-261833)
- Enzalutamide Impurity 48 (CAS CATO-C4X-101648)
- (2-(3,3,3-Trifluoropropoxy)phenyl)methanamine (CAS 1343088-05-0)
- 6'-Methoxy-2',3',4',9'-tetrahydrospiro[cyclobutane-1,1'-pyrido[3,4-b]indole] (CAS 1956334-60-3)
- 2-Chloro-3-(difluoromethyl)-6-fluoropyridine-4-sulfonamide (CAS 1807041-52-6)
- Bortezomib Impurity 45 (CAS 110755-29-8)
- 7-Hydroxy Coumarin Glucuronide Sodium Salt (CAS 168286-98-4)
- (R)-4-cyano-N-(3-(cyclopropyl(4-hydroxy-2-oxo-5,6,7,8,9,10-hexahydro-2H-cycloocta[b]pyran-3-yl)methyl)phenyl)benzenesulfonamide (CAS 166335-16-6)
- Tirzepatide(sodium salt) (CAS 2023788-19-2(free base))
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com