2-Bromo-4-(difluoromethyl)pyrimidine CAS 1784944-35-9
| CAS No. | 1784944-35-9 |
| Molecular Formula | C5H3BrF2N2 |
| Molecular Weight | 208.99 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 208.99 g/mol gives 2-Bromo-4-(difluoromethyl)pyrimidine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies 2-Bromo-4-(difluoromethyl)pyrimidine (CAS 1784944-35-9), a certified reference material (molecular formula C5H3BrF2N2, MW 208.99 g/mol) for analytical method development and quality control.
The molecular framework of 2-Bromo-4-(difluoromethyl)pyrimidine (C5H3BrF2N2) is characterized by a nitrile group, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Bromo-4-(difluoromethyl)pyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H3BrF2N2 |
| Molecular Weight | 208.99 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related Bromo Standards
- 4-Bromo-2,6-difluorophenol (CAS 104197-13-9)
- 2-Bromo-3,6-difluorophenol (CAS 1208077-18-2)
- (Z)-3-bromo-4-methoxy-4-oxobut-2-enoic acid (CAS 122457-36-7)
- 5-Bromo-3,6-difluoropyridin-2-amine (CAS 1267856-70-1)
- 4-Bromo-3,5-difluorophenol (CAS 130191-91-2)
- 2-Bromo-3,4-difluorophenol (CAS 1376335-05-5)
- 4-Bromo-2,3-difluorophenol (CAS 144292-32-0)
- 3-Bromo-2,4-difluorophenol (CAS 1541784-30-8)
Recommended Standards
- 3-Bromo-2,5-difluorophenol (CAS 1783357-67-4)
- 2-Bromo-5-(difluoromethyl)pyrazine (CAS 1785427-24-8)
- 5-Bromo-2-(difluoromethyl)pyrimidine (CAS 1780834-92-5)
- 3-Bromo-4,5-difluorophenol (CAS 1807120-34-8)
- 2-(Iodomethyl)spiro[3.3]heptane (CAS 1706434-86-7)
- 2-amino-3-{bicyclo[1.1.1]pentan-1-yl}propanoic acid (CAS 1934279-44-3)
- 1-Amino-2-(2,5-dimethylphenyl)propan-2-ol (CAS 1017419-02-1)
- (1R,3R)-N-Boc-3-aminocyclohexanecarboxylic Acid (CAS 1430938-32-1)
- 5β-Cholestane (CAS 481-20-9)
- 1-Aminohydantoin Hydrochloride (CAS 2827-56-7)
- Samarium 149 (CAS 14392-34-8)
- 4-(6-Fluoropyridin-2-yl)benzonitrile (CAS 1245646-03-0)
- 5-((1-(2-(2,4-Dimethylphenoxy)ethyl)-2-methyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione (CAS 667880-38-8)
- Des-[Gly]31-Semaglutide(x TFA Salt) (CAS 873874-39-6(free base))
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