4,4-Difluoropyrrolidin-2-one CAS 1785332-67-3
| CAS No. | 1785332-67-3 |
| Molecular Formula | C4H5F2NO |
| Molecular Weight | 121.09 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4,4-Difluoropyrrolidin-2-one.
CATO supplies 4,4-Difluoropyrrolidin-2-one (CAS 1785332-67-3), a certified reference material (molecular formula C4H5F2NO, MW 121.09 g/mol) for analytical method development and quality control.
The molecular framework of 4,4-Difluoropyrrolidin-2-one (C4H5F2NO) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4,4-Difluoropyrrolidin-2-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C4H5F2NO |
| Molecular Weight | 121.09 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoropyrrolidin Standards
- 3,3-Difluoropyrrolidin-1-amine (CAS 1260787-88-9)
- 4,4-Difluoropyrrolidin-3-amine (CAS 1804969-95-6)
- (R)-4,4-difluoropyrrolidin-3-ol (CAS 1433946-75-8)
- 4,4-Difluoropyrrolidin-3-ol (CAS 1638920-21-4)
- (S)-4,4-difluoropyrrolidin-3-ol (CAS 2344751-62-6)
- (S)-(4,4-Difluoropyrrolidin-2-yl)methanamine (CAS 1821494-02-3)
- (R)-(4,4-Difluoropyrrolidin-2-yl)methanamine (CAS 1821494-05-6)
- (3,3-Difluoropyrrolidin-2-yl)methanol (CAS 1027519-80-7)
Recommended Standards
- 3,3-Difluoro-2-pyrrolidinone (CAS 162970-49-2)
- (R)-2,2-difluorocyclopropane-1-carboxamide (CAS 2165629-40-1)
- 2-(2,2-Difluoroethoxy)acetonitrile (CAS 1553618-82-8)
- (S)-2,2-difluorocyclopropane-1-carboxamide (CAS 2165956-38-5)
- 7-O-(Trifluoroacetyl) Baccatin III (CAS 158811-19-9)
- 2-Chlorofuro[3,4-b]pyridin-7(5H)-one (CAS 1352886-74-8)
- Furan-2-yl(4-(methylthio)phenyl)methanol (CAS 944697-88-5)
- 4-[4-Methyl-2-(pyridin-4-yl)-1,3-thiazol-5-yl]pyrimidine (CAS 499796-08-6)
- 1-(4-Chlorophenoxy)-3,3-dimethylbutan-2-one (CAS 24473-06-1)
- N-(4-Methoxyphenyl)-5-methyl-12-oxo-5H,5aH,6H,7H,8H,9H,10H,12H-azepino[2,1-b]quinazoline-3-carboxamide (CAS 1775359-35-7)
- 2-Bromo-5-ethyl-4-nitropyridine (CAS 1804897-58-2)
- 4-chloro-2-methyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine (CAS 2209847-69-6)
- N-(3,4-Dichlorophenyl)-1H-benzo[d]imidazol-2-amine (CAS 917974-36-8)
- D-Lys16-Tirzepatide (CAS CATO-CPTD788918)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
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