3,3-Difluoro-2-pyrrolidinone CAS 162970-49-2
| CAS No. | 162970-49-2 |
| Molecular Formula | C4H5F2NO |
| Molecular Weight | 121.09 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 121.09 g/mol gives 3,3-Difluoro-2-pyrrolidinone distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
3,3-Difluoro-2-pyrrolidinone (CAS 162970-49-2), molecular formula C4H5F2NO and molecular weight 121.09 g/mol, is a CATO reference standard with documented purity and traceability.
3,3-Difluoro-2-pyrrolidinone (C4H5F2NO) contains an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4H5F2NO |
| Molecular Weight | 121.09 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoro Standards
- 3,3-Difluoro-1-methylcyclobutan-1-amine (CAS 1408076-03-8)
- 3,3-Difluoro-4-methylpyrrolidine (CAS 1554367-59-7)
- (2R)-4,4-Difluoro-2-methylpyrrolidine (CAS 1670259-97-8)
- (2S)-4,4-Difluoro-2-methylpyrrolidine (CAS 1670259-98-9)
- 2,2-Difluoro-cyclopropaneboronic acid (CAS 2408428-30-6)
- 5,5-Difluoro-1-oxaspiro[2.3]hexane (CAS 1197420-24-8)
- 2,2-Difluoro-1-methylcyclopropane-1-carbaldehyde (CAS 128230-70-6)
- 2,2-Difluoro-3,4-dihydro-2H-pyrrol-5-amine (CAS 802002-40-0)
Recommended Standards
- 2-(2,2-Difluoroethoxy)acetonitrile (CAS 1553618-82-8)
- 4,4-Difluoropyrrolidin-2-one (CAS 1785332-67-3)
- 4-Formylfuran-2-carbonitrile (CAS 1369347-89-6)
- (R)-2,2-difluorocyclopropane-1-carboxamide (CAS 2165629-40-1)
- Methyl 5-chloromethyl-2,4-dimethoxybenzoate (CAS 92492-35-8)
- [3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methanol (CAS 36640-39-8)
- 5-(3,4-Dimethoxyphenyl)-4-methyl-4H-1,2,4-triazole-3-thiol (CAS 174573-92-3)
- 2-Chloro-5-fluoro-7-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (CAS 1638771-04-6)
- 5,6,7,8-Tetrahydroquinoxalin-5-ol (CAS 35149-13-4)
- 1-Acetyl-3-hydroxyazetidine (CAS 118972-96-6)
- 7-Hydroxy-2H-benzo[d][1,3]oxazine-2,4(1H)-dione (CAS 1394918-88-7)
- Lidocaine EP Impurity E Hydrochloride (CAS 1135231-62-7)
- 3-((Piperidin-3-yloxy)methyl)pyridine (CAS 933758-64-6)
- Semaglutide Impurity 149 (CAS CATO-C4X-2226149)
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