Levofloxacin EP Impurity I CAS 178912-62-4
| CAS No. | 178912-62-4 |
| Molecular Formula | C18H20FN3O4 |
| Molecular Weight | 361.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Levofloxacin EP Impurity I.
CATO supplies Levofloxacin EP Impurity I (CAS 178912-62-4), a pharmacopoeial impurity reference standard (molecular formula C18H20FN3O4, MW 361.37 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C18H20FN3O4, Levofloxacin EP Impurity I contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 361.37 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H20FN3O4 |
| Molecular Weight | 361.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2008 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Levofloxacin Standards
- Levofloxacin Impurity 1 (CAS 178912-61-3)
- Levofloxacin R-Isomer（Levofloxacin EP Impurity A） (CAS 100986-86-5)
- Levofloxacin Impurity 8 (CAS 2489671-28-3)
- Levofloxacin (CAS 100986-85-4)
- Levofloxacin impurity 77 (CAS CATO-C4X-137177)
- Levofloxacin Impurity 80 (CAS CATO-C4X-137180)
- Levofloxacin Impurity 62 (CAS CATO-C4X-137162)
- Levofloxacin Impurity 87 (CAS CATO-C4X-137187)
Recommended Standards
- Gatifloxacin Impurity 3 (CAS 616205-76-6)
- Ofloxacin EP Impurity D (CAS 197291-75-1)
- Gatifloxacin Related Compound D(3-Desmethyl Gatifloxacin) (CAS 112811-57-1)
- N-Acetylnorfloxacin (CAS 74011-56-6)
- Racecadotril Impurity 26 (CAS CATO-C4X-110626)
- Parecoxib Impurity 32 (CAS 181696-12-8)
- Simvastatin EP Impurity J (CAS 864357-88-0)
- (6-Chloro-2-methoxypyrimidin-4-yl)methanol (CAS 2072804-89-6)
- 2-Methoxy-N-methyl-5-nitroaniline (CAS 19871-39-7)
- 2-((Benzyloxy)methyl)-3,4-dihydro-2h-pyran (CAS 194861-23-9)
- 6-Methyl-1H-pyrrolo[2,3-b]pyridin-3-amine (CAS 1000340-30-6)
- (3-(2,2,2-Trifluoroethyl)phenyl)boronic acid (CAS 1620056-82-7)
- [1,1'-Biphenyl]-3,3',4,4'-tetracarboxylic acid (CAS 22803-05-0)
- Semaglutide Impurity 2 (CAS CATO-C4X-22262)
Why CATO?
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