Ofloxacin EP Impurity D CAS 197291-75-1
| CAS No. | 197291-75-1 |
| Molecular Formula | C18H20FN3O4 |
| Molecular Weight | 361.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ofloxacin EP Impurity D.
Ofloxacin EP Impurity D (CAS 197291-75-1) is a certified pharmaceutical impurity reference standard with the molecular formula C18H20FN3O4 and a molecular weight of 361.37 g/mol.
Structurally, Ofloxacin EP Impurity D (C18H20FN3O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 361.37 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ofloxacin EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H20FN3O4 |
| Molecular Weight | 361.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2013 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Ofloxacin Standards
- Ofloxacin (CAS 82419-36-1)
- (R)-Ofloxacin-d3 (CAS 1346617-10-4)
- Ofloxacin-D3 (CAS 1173147-91-5)
- Ofloxacin-d8 (CAS 1219170-21-4)
- Ofloxacin Desethylene Impurity (CAS 1797983-25-5)
- Ofloxacin EP Impurity E (CAS 82419-52-1)
- Ofloxacin EP Impurity F(Levofloxacin Impurity 25) (CAS 104721-52-0)
- Ofloxacin impurity 11 (CAS CATO-C4X-171711)
Recommended Standards
- Levofloxacin EP Impurity I (CAS 178912-62-4)
- Levofloxacin R-Isomer（Levofloxacin EP Impurity A） (CAS 100986-86-5)
- Gatifloxacin Impurity 3 (CAS 616205-76-6)
- Levofloxacin Impurity 8 (CAS 2489671-28-3)
- Ribavirin Impurity 43 (CAS 645-15-8)
- Labetalol Impurity 71 (CAS CATO-C4X-246671)
- Tetracaine Impurity 37 (CAS 512175-79-0 (free base))
- Sodium 3-ethyl-7-isopropylazulene-1-sulfonate (CAS 97683-31-3)
- (E)-4-Oxodec-2-enal (CAS 92464-81-8)
- 2-Chloro-5-isopropylbenzaldehyde (CAS 1288991-69-4)
- 2-Chloro-5-(piperidine-1-sulfonyl)benzoic acid (CAS 109029-95-0)
- N-(L-Leucyl)-2-aminoacridone (CAS 124689-91-4)
- N-(4-chlorophenyl)-4-cyano-3-(trifluoromethyl)-1H-pyrazole-1-carboxamide (CAS 321574-28-1)
- Tau Peptide (306-317) trifluoroacetate salt (CAS 1003007-59-7)
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