1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]urea CAS 1796920-11-0
| CAS No. | 1796920-11-0 |
| Molecular Formula | C24H18ClF3N4O2 |
| Molecular Weight | 486.87 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]urea.
CATO supplies 1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]urea (CAS 1796920-11-0), a certified reference material (molecular formula C24H18ClF3N4O2, MW 486.87 g/mol) for analytical method development and quality control.
The molecular framework of 1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]urea (C24H18ClF3N4O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]urea under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C24H18ClF3N4O2 |
| Molecular Weight | 486.87 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Chloro Standards
- 3-[4-Chloro-2-(trifluoromethyl)phenyl]-1-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)urea (CAS 1796882-68-2)
- 1-[2-Chloro-4-(trifluoromethyl)phenyl]-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)urea (CAS 1796904-73-8)
- 2-((4-Chloro-N-(3-(trifluoromethyl)phenyl)phenyl)sulfonamido)-N-(2-fluorophenyl)acetamide (CAS 337922-23-3)
- 4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[(1E)-{[(4-nitrophenyl)methoxy]amino}methylidene]piperazine-1-carboxamide (CAS 339029-32-2)
- Ethyl 10-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-9,11-dioxo-3-oxa-4,10-diazatetracyclo[5.5.1.0^{2,6}.0^{8,12}]tridec-4-ene-5-carboxylate (CAS 321385-52-8)
- 2-Chloro-N1,N4-bis(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)terephthalamide (CAS 70-09-7)
- 1-Chloro-4-(4-chloro-1,1,2,2,3,3,4,4-octafluorobutoxy)-1,1,2,2,3,3,4,4-octafluorobutane (CAS 149697-40-5)
- 1-(2-{[4-(3-chloro-4-methoxyphenyl)-5-phenyl-4h-1,2,4-triazol-3-yl]sulfanyl}acetyl)piperidine-4-carboxylic acid (CAS 731801-15-3)
Recommended Standards
- 3-(4-Chlorophenyl)-N-(3-(imidazo[1,2-a]pyridin-2-yl)phenyl)-3-(2,2,2-trifluoroacetamido)propanamide (CAS 866039-29-4)
- Norepinephrine impurity 145 (CAS CATO-C4X-1514145)
- (5-(4-Chlorophenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)methanone (CAS 1072874-79-3)
- 4-Acetamidophenyl 4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}benzene-1-sulfonate (CAS 338400-17-2)
- 4,4'-(9,9-Dimethyl-9H-fluorene-2,7-diyl)dibenzoic acid (CAS 1217979-48-0)
- Methyl (R)-2-amino-3-(6-(trifluoromethyl)pyridin-3-yl)propanoate (CAS 1213341-81-1)
- (4-Methyl-4-(pyridin-3-yl)pyrrolidin-3-yl)methanol (CAS 1823671-99-3)
- isopropyl 4-[(2-chloropropanoyl)amino]benzoate (CAS 1050883-91-4)
- Azilsartan Impurity 63 (CAS 985638-55-8)
- 1-(5-(4-(tert-Butyl)phenyl)-4-chlorothiophen-2-yl)ethan-1-one (CAS 1309597-88-3)
- 8-((5'-Amino-2'-Methyl-3'-Thiapentyl)Amino)-6-Methoxy-4-Methyl-5-((3-Trifluoromethyl)Phenoxy)Quinoline (CAS 98586-87-9)
- tert-Butyl 3-hydroxy-5-oxopiperidine-1-carboxylate (CAS 1934640-29-5)
- 4-(4-Bromo-3-(difluoromethyl)-1H-pyrazol-1-yl)butanoic acid (CAS 1855944-81-8)
- Des-Gln24-Tirzepatide (CAS CATO-CPTD788949)
Why CATO?
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