3-(4-Chlorophenyl)-N-(3-(imidazo[1,2-a]pyridin-2-yl)phenyl)-3-(2,2,2-trifluoroacetamido)propanamide CAS 866039-29-4
| CAS No. | 866039-29-4 |
| Molecular Formula | C24H18ClF3N4O2 |
| Molecular Weight | 486.87 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 3-(4-Chlorophenyl)-N-(3-(imidazo[1,2-a]pyridin-2-yl)phenyl)-3-(2,2,2-trifluoroacetamido)propanamide (C24H18ClF3N4O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
3-(4-Chlorophenyl)-N-(3-(imidazo[1,2-a]pyridin-2-yl)phenyl)-3-(2,2,2-trifluoroacetamido)propanamide (CAS 866039-29-4), molecular formula C24H18ClF3N4O2 and molecular weight 486.87 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-(4-Chlorophenyl)-N-(3-(imidazo[1,2-a]pyridin-2-yl)phenyl)-3-(2,2,2-trifluoroacetamido)propanamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H18ClF3N4O2 |
| Molecular Weight | 486.87 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Chlorophenyl Standards
- (5-(4-Chlorophenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)methanone (CAS 1072874-79-3)
- [(4-Chlorophenyl)thiomethylene]biphosphonic Acid, Tetraisopropyl Ester (CAS 89987-31-5)
- Methyl 2-(2-(4-chlorophenyl)acetamido)-5-((2-ethoxyphenyl)carbamoyl)-4-methylthiophene-3-carboxylate (CAS 335409-31-9)
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- 3-(4-Chlorophenyl)-1-(2-nitro-4-(trifluoromethyl)phenyl)-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine (CAS 338770-83-5)
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- 1-(4-Chlorophenyl)-3-{3-[(4-chlorophenyl)sulfanyl]-5-(trifluoromethyl)pyridine-2-carbonyl}urea (CAS 338759-10-7)
Recommended Standards
- 2-((4-Chloro-N-(3-(trifluoromethyl)phenyl)phenyl)sulfonamido)-N-(2-fluorophenyl)acetamide (CAS 337922-23-3)
- 1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]urea (CAS 1796920-11-0)
- 3-Cyano-4-(3-chloro-4-fluoroanilino)-7-ethoxy-6-(phthalimidyl)quinoline 915945-40-3 (CAS 915945-40-3)
- 1-[2-Chloro-4-(trifluoromethyl)phenyl]-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)urea (CAS 1796904-73-8)
- 2-(5-Bromo-2-oxo-2,3-dihydro-1H-indol-1-yl)acetic acid (CAS 881609-04-7)
- Sodium 3-(1-methyl-2-(3-(1-methyl-3-(3-sulfonatopropyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-ylidene)prop-1-en-1-yl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-3-ium-3-yl)propane-1-sulfonate (CAS 63815-86-1)
- tert-Butyl ((6-amino-4-methylpyridin-3-yl)methyl)carbamate (CAS 1355190-41-8)
- N-(4-(4-((Aminothioxomethyl)amino)-3,5-thiazolyl)phenyl)ethanamide (CAS 1024288-27-4)
- 2-(Difluoromethyl)-4-hydroxy-5-methylpyridine-3-carboxylic acid (CAS 1805256-26-1)
- N-(2-((4-Phenylpiperazin-1-yl)sulfonyl)ethyl)-2-(thiophen-2-yl)acetamide (CAS 897621-83-9)
- 4-(Aminocarbonyl)-3,5-difluorophenylboronic acid (CAS 924279-82-3)
- Brevetoxin B (CAS 79580-28-2)
- 3-Isocyanatoprop-1-yne (CAS 56620-43-0)
- Tirzepatide Impurity 18 (CAS CATO-C4X-324018)
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