Flurbiprofen EP Impurity B (Mixture of Diastereomers) CAS 1797883-74-9
| CAS No. | 1797883-74-9 |
| Molecular Formula | C18H17FO4 |
| Molecular Weight | 316.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Flurbiprofen EP Impurity B (Mixture of Diastereomers) (CAS 1797883-74-9), a pharmacopoeial impurity reference standard (molecular formula C18H17FO4, MW 316.32 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution, Flurbiprofen EP Impurity B (Mixture of Diastereomers) is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 316.32 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H17FO4 |
| Molecular Weight | 316.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
Related Flurbiprofen Standards
- Flurbiprofen Impurity 124 (CAS CATO-C4X-1444124)
- Flurbiprofen Impurity 172 (CAS 543688-88-6)
- Flurbiprofen Impurity 19 (CAS CATO-C4X-144419)
- Flurbiprofen Impurity 21 (Mixture of Diastereomers) (CAS 124635-84-3)
- Flurbiprofen Impurity 46 (CAS CATO-C4X-144446)
- Flurbiprofen 2-Glyceryl Ester (CAS 124635-86-5)
- Flurbiprofen Impurity 18 (CAS 78543-06-3)
- Flurbiprofen Impurity 54 (CAS CATO-C4X-144454)
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