Flurbiprofen Impurity 46 CAS CATO-C4X-144446
| CAS No. | CATO-C4X-144446 |
| Molecular Formula | C18H19FO4 |
| Molecular Weight | 318.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Flurbiprofen Impurity 46 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Flurbiprofen Impurity 46 (CAS CATO-C4X-144446, C18H19FO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C18H19FO4, Flurbiprofen Impurity 46 contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 318.34 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H19FO4 |
| Molecular Weight | 318.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
Related Flurbiprofen Standards
- Flurbiprofen Impurity 19 (CAS CATO-C4X-144419)
- Flurbiprofen Impurity 21 (Mixture of Diastereomers) (CAS 124635-84-3)
- Flurbiprofen 2-Glyceryl Ester (CAS 124635-86-5)
- Flurbiprofen Impurity 67 (CAS CATO-C4X-144467)
- Flurbiprofen Impurity 124 (CAS CATO-C4X-1444124)
- Flurbiprofen Impurity 172 (CAS 543688-88-6)
- Flurbiprofen EP Impurity B (Mixture of Diastereomers) (CAS 1797883-74-9)
- Flurbiprofen Impurity 165 (CAS CATO-C4X-1444165)
Recommended Standards
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- Landiolol Impurity 73 (CAS CATO-C4X-262173)
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- Cefepime Impurity 19 (CAS CATO-C4X-119319)
- Etrasimod Impurity 42 (CAS 2863532-89-0)
- Apixaban Impurity 96 (CAS 2512213-45-3)
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