Flurbiprofen Impurity 21 (Mixture of Diastereomers) CAS 124635-84-3
| CAS No. | 124635-84-3 |
| Molecular Formula | C18H19FO4 |
| Molecular Weight | 318.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Flurbiprofen Impurity 21 (Mixture of Diastereomers) is closely related to a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Flurbiprofen Impurity 21 (Mixture of Diastereomers) (CAS 124635-84-3, C18H19FO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution, Flurbiprofen Impurity 21 (Mixture of Diastereomers) is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 318.34 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H19FO4 |
| Molecular Weight | 318.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >80% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
Related Flurbiprofen Standards
- Flurbiprofen Impurity 19 (CAS CATO-C4X-144419)
- Flurbiprofen Impurity 46 (CAS CATO-C4X-144446)
- Flurbiprofen 2-Glyceryl Ester (CAS 124635-86-5)
- Flurbiprofen Impurity 67 (CAS CATO-C4X-144467)
- Flurbiprofen Impurity 124 (CAS CATO-C4X-1444124)
- Flurbiprofen Impurity 172 (CAS 543688-88-6)
- Flurbiprofen EP Impurity B (Mixture of Diastereomers) (CAS 1797883-74-9)
- Flurbiprofen Impurity 165 (CAS CATO-C4X-1444165)
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