Flurbiprofen Impurity 172 CAS 543688-88-6
| CAS No. | 543688-88-6 |
| Molecular Formula | C18H17FO4 |
| Molecular Weight | 316.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Flurbiprofen Impurity 172 (C18H17FO4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Flurbiprofen Impurity 172 (CAS 543688-88-6, C18H17FO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Flurbiprofen Impurity 172 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H17FO4 |
| Molecular Weight | 316.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F-containing |
Related Flurbiprofen Standards
- Flurbiprofen Impurity 124 (CAS CATO-C4X-1444124)
- Flurbiprofen EP Impurity B (Mixture of Diastereomers) (CAS 1797883-74-9)
- Flurbiprofen Impurity 19 (CAS CATO-C4X-144419)
- Flurbiprofen Impurity 21 (Mixture of Diastereomers) (CAS 124635-84-3)
- Flurbiprofen Impurity 46 (CAS CATO-C4X-144446)
- Flurbiprofen 2-Glyceryl Ester (CAS 124635-86-5)
- Flurbiprofen Impurity 18 (CAS 78543-06-3)
- Flurbiprofen Impurity 54 (CAS CATO-C4X-144454)
Recommended Standards
- Levofolinate Impurity 8 (CAS 4299-32-5)
- 4-(Difluoromethyl)-6-(1,3-dimethyl-1h-pyrazol-4-yl)-2-(ethylsulfonyl)pyrimidine (CAS 1006327-15-6)
- Levosimendan Impurity 6 (CAS CATO-C4X-13086)
- 1-[isocyano(4-methylbenzenesulfonyl)methyl]-3-nitrobenzene 1029104-25-3 KS-00001OSI (CAS 1029104-25-3)
- Levosimendan Impurity 31 (CAS 131741-05-4)
- Morpholine Impurity 7 (CAS CATO-C4X-31687)
- Lafutidine Impurity 24 (CAS 146270-02-2)
- Dapoxetine Impurity 75 (CAS 2687-12-9)
- Benzyl 2-(hydroxymethyl)-7-azaspiro[3.5]Nonane-7-carboxylate (CAS 2222604-15-9)
- N-[(9R)-6'-Methoxycinchonan-9-yl]-4-trifluoromethyl-1,2-benzenediamine (CAS 1404088-26-1)
- [2-(Methylsulfanyl)phenyl]methyl N-(3-chlorophenyl)carbamate (CAS 338968-10-8)
- 4-(2-Hydroxyethyl)-1-((4-methoxyphenyl)sulfonyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one (CAS 866040-29-1)
- (5E)-5-[(5-Bromo-2-furyl)methylene]-2-mercapto-3-phenyl-3,5-dihydro-4H-imidazol-4-one (CAS 1142201-50-0)
- Semaglutide impurity 29 (CAS 1188328-22-4)
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