Regorafenib EP Impurity A CAS 757251-39-1
| CAS No. | 757251-39-1 |
| Molecular Formula | C13H12FN3O2 |
| Molecular Weight | 261.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Regorafenib EP Impurity A (CAS 757251-39-1) is a certified pharmaceutical impurity reference standard with the molecular formula C13H12FN3O2 and a molecular weight of 261.25 g/mol.
Based on its molecular formula C13H12FN3O2, Regorafenib EP Impurity A contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 261.25 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Regorafenib EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H12FN3O2 |
| Molecular Weight | 261.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Regorafenib Standards
- Regorafenib Impurity 32 (CAS CATO-C4X-104732)
- Regorafenib Impurity 51 (CAS CATO-C4X-104751)
- Regorafenib Impurity 36 (CAS 864245-61-4)
- Regorafenib Impurity 40 (CAS CATO-C4X-104740)
- Regorafenib Impurity 48 (CAS CATO-C4X-104748)
- Regorafenib Impurity 40 (CAS 2711-18-4)
- Regorafenib Impurity 43 (CAS 1798046-84-0)
- Regorafenib Impurity 5 (CAS 19448-54-5)
Recommended Standards
- Flupirtine Impurity 4 (CAS 1506942-35-3)
- Carbamic acid, N-[3-fluoro-4-(hydroxymethyl)phenyl]-, phenyl ester (CAS 1402585-33-4)
- N-Cyclohexyl-6-(Trifluoromethyl)-1,3,5-Triazine-2,4-Diamine (CAS 788-01-2)
- Flumequine (CAS 42835-25-6)
- Budesonide Impurity 40 (CAS 91160-89-3)
- Imipenem Impurity 10 (CAS CATO-C4X-166210)
- Meropenem EP Impurity A (CAS 1053703-36-8)
- (4-Bromo-6-chloro-5-(difluoromethyl)pyridin-2-yl)methanol (CAS 1804459-76-4)
- 5-Bromo-3-(trifluoromethyl)picolinamide (CAS 1805142-81-7)
- 7-hydroxy-1H-indole-3-carboxylic acid (CAS 24370-79-4)
- (2E,4E,6E)-Ethyl 3-methyl-6-(2-((2-(trifluoromethyl)phenyl)sulfonyl)hydrazono)hexa-2,4-dienoate (CAS 2765851-45-2)
- 1,5-Dimethyl-1h-pyrazole-3-sulfonamide (CAS 1375474-25-1)
- 3-((2-(Diisopropylamino)ethyl)amino)tetrahydrothiophene 1,1-dioxide (CAS 900640-96-2)
- Liraglutide(3-31)TFA Salt (CAS CATO-C4X-19921)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com