Regorafenib Impurity 36 CAS 864245-61-4
| CAS No. | 864245-61-4 |
| Molecular Formula | C13H11FN2O3 |
| Molecular Weight | 262.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Regorafenib Impurity 36 (CAS 864245-61-4), a pharmacopoeial impurity reference standard (molecular formula C13H11FN2O3, MW 262.24 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Regorafenib Impurity 36 (C13H11FN2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C13H11FN2O3 |
| Molecular Weight | 262.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Regorafenib Standards
- Regorafenib EP Impurity A (CAS 757251-39-1)
- Regorafenib Impurity 32 (CAS CATO-C4X-104732)
- Regorafenib Impurity 51 (CAS CATO-C4X-104751)
- Regorafenib Impurity 40 (CAS CATO-C4X-104740)
- Regorafenib Impurity 48 (CAS CATO-C4X-104748)
- Regorafenib Impurity 40 (CAS 2711-18-4)
- Regorafenib Impurity 43 (CAS 1798046-84-0)
- Regorafenib Impurity 31 (CAS CATO-C4X-104731)
Recommended Standards
- Flupirtine Impurity 2 (CAS 33400-49-6)
- Clavulanate Potassium EP Impurity B sodium salt (CAS 96681-85-5(free acid))
- n-(3-Amino-4-fluorophenyl)-2-(2-oxo-1,2-dihydropyrimidin-1-yl)acetamide (CAS 953732-34-8)
- Ciprofloxacin Impurity 30 (CAS 105674-91-7)
- Fulvestrant impurity 48 (CAS CATO-C4X-191748)
- Pregabalin Impurity 31 (CAS 185815-56-9)
- Cefdinir Impurity 52 (CAS 66338-96-3)
- (Z)-tert-Butyl 3-(2-ethoxy-2-oxoethylidene)-4-oxopiperidine-1-carboxylate (CAS 1422462-67-6)
- 1-BROMO-2-FLUORO-3-METHYL-BENZENE 2-FLUORO-3-BROMO TOLUENE 2-FLUORO-3-METHYL-BROMOBENZENE 3-BROMO-2-FLUOROTOLUENE 59907-12-9 BC002784 BENZENE, 1-BROMO-2-FLUORO-3-METHYL- (CAS 59907-12-9)
- 2-(Azetidin-3-yl)-n-[(4-fluorophenyl)methyl]acetamide (CAS 1339196-74-5)
- Dolutegravir Impurity 50 (CAS CATO-C4X-162050)
- (2R,3R)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-3-(3-methoxyphenyl)propanoic acid (CAS 1217620-43-3)
- n,n-Dimethyl-2-(piperidin-3-yl)acetamide (CAS 138304-50-4)
- Insulin Glargine Metabolite M2 (CAS CATO-CPTD788867)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com