Crizotinib Impurity 41 CAS 1801651-84-2
| CAS No. | 1801651-84-2 |
| Molecular Formula | C21H23ClFN5O |
| Molecular Weight | 415.89 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Crizotinib Impurity 41 (CAS 1801651-84-2) is a certified pharmaceutical impurity reference standard with the molecular formula C21H23ClFN5O and a molecular weight of 415.89 g/mol.
Based on its molecular formula C21H23ClFN5O, Crizotinib Impurity 41 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 415.89 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C21H23ClFN5O |
| Molecular Weight | 415.89 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Crizotinib Standards
- Crizotinib impurity 30 (CAS CATO-C4X-102530)
- Crizotinib impurity 31 (CAS CATO-C4X-102531)
- Crizotinib impurity 32 (CAS CATO-C4X-102532)
- Crizotinib Impurity 48 (CAS CATO-C4X-102548)
- Crizotinib Impurity 49 (CAS CATO-C4X-102549)
- Crizotinib Impurity 74 (CAS CATO-C4X-102574)
- Crizotinib Impurity 55 (CAS CATO-C4X-102555)
- Crizotinib impurity 29 (CAS CATO-C4X-102529)
Recommended Standards
- N-(1-(1-(4-Chlorophenyl)-1H-1,2,3-triazole-4-carbonyl)piperidin-4-yl)thiophene-2-carboxamide (CAS 1251696-23-7)
- Milenperone (CAS 59831-64-0)
- 2-((4-Allyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(3-chloro-4-methoxyphenyl)acetamide (CAS 577762-32-4)
- Ethyl 4-(4-chlorophenyl)-5-formyl-2-methyl-6-(pyrimidin-2-ylsulfanyl)-1,4-dihydropyridine-3-carboxylate (CAS 478261-85-7)
- Darolutamide Impurity 17 (CAS CATO-C4X-310617)
- Quinapril EP Impurity C (CAS 82768-85-2)
- Pelubiprofen Impurity N1 (CAS 63476-54-0)
- tert-Butyl 3-(aminomethyl)-3-methylazetidine-1-carboxylate (CAS 1158758-85-0)
- (S)-2-(2-Bromophenyl)-4-(tert-butyl)-4,5-dihydrooxazole (CAS 154701-60-7)
- N-(5-bromo-2-methoxybenzyl)cycloheptanamine hydrobromide (CAS 1609395-64-3)
- Ethyl 6-(2-methoxy-2-oxoethyl)-4-[3-(trifluoromethyl)benzenesulfonyl]-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylate (CAS 866134-81-8)
- methyl 5-[(4-ethylphenoxy)methyl]-2-furoate (CAS 402772-24-1)
- 5,7-Dichloro-2-methylbenzofuran (CAS 42969-85-7)
- Semaglutide impurity 28 (CAS CATO-C4X-222628)
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