Crizotinib Impurity 55 CAS CATO-C4X-102555
| CAS No. | CATO-C4X-102555 |
| Molecular Formula | C21H23Cl2N5O |
| Molecular Weight | 432.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 432.35 g/mol gives Crizotinib Impurity 55 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Crizotinib Impurity 55 (CAS CATO-C4X-102555), a pharmacopoeial impurity reference standard (molecular formula C21H23Cl2N5O, MW 432.35 g/mol) used for the identification and quantification of trace impurities in APIs.
Crizotinib Impurity 55 (C21H23Cl2N5O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H23Cl2N5O |
| Molecular Weight | 432.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Crizotinib Standards
- Crizotinib impurity 30 (CAS CATO-C4X-102530)
- Crizotinib impurity 31 (CAS CATO-C4X-102531)
- Crizotinib impurity 32 (CAS CATO-C4X-102532)
- Crizotinib Impurity 41 (CAS 1801651-84-2)
- Crizotinib Impurity 48 (CAS CATO-C4X-102548)
- Crizotinib Impurity 49 (CAS CATO-C4X-102549)
- Crizotinib (CAS 877399-52-5)
- Crizotinib impurity 20 (CAS CATO-C4X-102520)
Recommended Standards
- Tert-butyl 3-bromo-5,6-dihydrospiro[benzo[d]imidazo[1,2-a]azepine-11,4'-piperidine]-1'-carboxylate (CAS 279254-14-7)
- 6-(((Bis(2-cyanoethoxy)phosphoryl)oxy)methyl)-2,2-dimethyltetrahydro-4H-furo[3,2-d][1,3]dioxin-7-yl acetate (CAS 1041021-85-5)
- (3-Nitro-4-phenoxyphenyl)methyl N-[3-(trifluoromethyl)phenyl]carbamate (CAS 338960-92-2)
- 4,4,5,5-Tetramethyl-2-(5'-phenyl-[1,1':3',1''-terphenyl]-3-yl)-1,3,2-dioxaborolane (CAS 1257248-43-3)
- Imatinib Impurity 67 (CAS 2031255-25-9)
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- 3-(Thiomorpholin-4-ylmethyl)phenylboronic acid (CAS 1256358-59-4)
- 4-(Difluoromethyl)-3-iodo-5-methoxypicolinonitrile (CAS 1807094-69-4)
- 1-(5-Bromo-2-ethoxyphenyl)ethanone (CAS 16602-11-2)
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- Mirogabalin Impurity 98 (CAS CATO-C4X-292498)
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Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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