Crizotinib Impurity 74 CAS CATO-C4X-102574
| CAS No. | CATO-C4X-102574 |
| Molecular Formula | C16H12Cl4F2O |
| Molecular Weight | 400.07 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Crizotinib Impurity 74 (CAS CATO-C4X-102574) is a certified pharmaceutical impurity reference standard with the molecular formula C16H12Cl4F2O and a molecular weight of 400.07 g/mol.
Based on its molecular formula C16H12Cl4F2O, Crizotinib Impurity 74 contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 400.07 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H12Cl4F2O |
| Molecular Weight | 400.07 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
Related Crizotinib Standards
- Crizotinib impurity 30 (CAS CATO-C4X-102530)
- Crizotinib impurity 31 (CAS CATO-C4X-102531)
- Crizotinib impurity 32 (CAS CATO-C4X-102532)
- Crizotinib Impurity 41 (CAS 1801651-84-2)
- Crizotinib Impurity 48 (CAS CATO-C4X-102548)
- Crizotinib Impurity 49 (CAS CATO-C4X-102549)
- Crizotinib impurity 29 (CAS CATO-C4X-102529)
- Crizotinib Impurity 3 (CAS 877399-00-3)
Recommended Standards
- 1,3-Bis(5-bromo-3-methylpyridin-2-yl)urea (CAS 1263208-76-9)
- 2-(5'-BRomo-[2,2'-bithiophen]-5-yl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione (CAS 1104636-79-4)
- 2-Octene,1,1,1,2,3,4,4,5,5,6,6,7,7,8,8,8-hexadecafluoro- 65500-50-7 (CAS 65500-50-7)
- 1H,1H-Perfluorooctan-1-ol (CAS 307-30-2)
- Orforglipron Impurity 6 (CAS CATO-C4X-32346)
- Sorafenib Impurity 29 (CAS CATO-C4X-112429)
- Netupitant Impurity 53 (CAS CATO-C4X-122353)
- Vortioxetine Sulfoxide (CAS 763128-02-5)
- 1-((tert-Butoxycarbonyl)(methyl)amino)cyclobutanecarboxylic acid (CAS 1202858-82-9)
- Ibuprofen impurity 132 (CAS 3585-48-6)
- Isothiazolidine-4-carboxylic acid 1,1-dioxide (CAS 2387037-16-1)
- Flurbiprofen Impurity 126 (CAS CATO-C4X-1444126)
- Methyl 5-(benzo[d][1,3]dioxol-5-yl)picolinate (CAS 1799412-38-6)
- Semaglutide impurity 249 (CAS CATO-C4X-2226249)
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