5-(Trifluoromethyl)pyrimidin-4-amine CAS 1805131-89-8
| CAS No. | 1805131-89-8 |
| Molecular Formula | C5H4F3N3 |
| Molecular Weight | 163.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-(Trifluoromethyl)pyrimidin-4-amine is closely related to a nitrile group, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-(Trifluoromethyl)pyrimidin-4-amine (CAS 1805131-89-8) is a high-purity analytical reference standard with the molecular formula C5H4F3N3 and a molecular weight of 163.10 g/mol.
Structurally, 5-(Trifluoromethyl)pyrimidin-4-amine (C5H4F3N3) contains a nitrile group, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 163.10 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 5-(Trifluoromethyl)pyrimidin-4-amine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C5H4F3N3 |
| Molecular Weight | 163.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Trifluoromethyl Standards
- 4-(Trifluoromethyl)pyrimidin-5-amine (CAS 1092299-22-3)
- 5-(Trifluoromethyl)-1H-pyrrole-2-carbaldehyde (CAS 1367875-88-4)
- 3-(Trifluoromethyl)pyridin-4(1H)-one (CAS 140899-19-0)
- 5-(trifluoromethyl)-1H-pyrrole-3-carbaldehyde (CAS 1803567-44-3)
- 2-(Trifluoromethyl)pyridine 1-oxide (CAS 22253-71-0)
- 3-(Trifluoromethyl)pyridin-2-ol (CAS 22245-83-6)
- 4-(Trifluoromethyl)pyridine 1-oxide (CAS 22253-59-4)
- 6-(Trifluoromethyl)pyridin-3-ol (CAS 216766-12-0)
Recommended Standards
- 2-(Difluoromethyl)-5-fluoropyridin-4-ol (CAS 1804703-31-8)
- 3-(Difluoromethyl)-5-fluoropyridin-2(1H)-one (CAS 1805304-17-9)
- 2-(Difluoromethoxy)-4-fluoropyridine (CAS 1803729-42-1)
- 4-(Difluoromethyl)-5-fluoropyridin-2-ol (CAS 1805304-22-6)
- Methyl (2-(methylamino)ethyl)carbamate (CAS 79143-41-2)
- 1-[2-(Diethylamino)ethyl]-4-sulfanylidene-1,2,3,4,5,6,7,8-octahydroquinazolin-2-one (CAS 920250-50-6)
- 3-(2-formylphenoxy)propanamide (CAS 1094323-06-4)
- 3,3-Difluoroazetidin-1-amine hydrochloride (CAS 1263145-19-2)
- 5-Fluoro-[1,2,4]triazolo[1,5-a]pyridine (CAS 1427366-64-0)
- 3-Bromo-4-cyclopropoxyaniline (CAS 1243458-97-0)
- 5-Carbamoyl-1-(m-tolyl)-1H-pyrazole-4-carboxylic acid (CAS 103053-17-4)
- (5-Cyclopropoxy-2-fluorophenyl)(methyl)sulfane (CAS 1243396-77-1)
- (9H-Fluoren-9-yl)methyl (3-cyanophenyl)carbamate (CAS 1375084-45-9)
- Semaglutide Impurity 123 (CAS 71997-93-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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