2-(Trifluoromethyl)pyridine 1-oxide CAS 22253-71-0
| CAS No. | 22253-71-0 |
| Molecular Formula | C6H4F3NO |
| Molecular Weight | 163.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(Trifluoromethyl)pyridine 1-oxide (CAS 22253-71-0), molecular formula C6H4F3NO and molecular weight 163.10 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(Trifluoromethyl)pyridine 1-oxide (C6H4F3NO) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4F3NO |
| Molecular Weight | 163.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- 4-(Trifluoromethyl)pyrimidin-5-amine (CAS 1092299-22-3)
- 5-(Trifluoromethyl)-1H-pyrrole-2-carbaldehyde (CAS 1367875-88-4)
- 3-(Trifluoromethyl)pyridin-4(1H)-one (CAS 140899-19-0)
- 5-(trifluoromethyl)-1H-pyrrole-3-carbaldehyde (CAS 1803567-44-3)
- 5-(Trifluoromethyl)pyrimidin-4-amine (CAS 1805131-89-8)
- 3-(Trifluoromethyl)pyridin-2-ol (CAS 22245-83-6)
- 4-(Trifluoromethyl)pyridine 1-oxide (CAS 22253-59-4)
- 6-(Trifluoromethyl)pyridin-3-ol (CAS 216766-12-0)
Recommended Standards
- 2-(Difluoromethoxy)-6-fluoropyridine (CAS 947534-62-5)
- 2,3,5-Trifluoro-6-methoxypyridine (CAS 3746-18-7)
- (E)-3,4,6-Trifluoro-2-hydrazono-1,2-dihydropyridine (CAS 837365-01-2)
- 2,5,6-Trifluoropyridine-3,4-diamine (CAS 6256-96-8)
- (E)-11-(4-((4-Butylphenyl)diazenyl)phenoxy)undecyl methacrylate (CAS 869802-95-9)
- tert-Butyl n-(1-aminopentan-2-yl)carbamate (CAS 1342578-12-4)
- 3-(2,2,2-Trifluoroethyl)benzoic acid (CAS 114980-36-8)
- (S)-3-(3-Acetylphenyl)-2-oxooxazolidine-5-carboxylic acid (CAS 918543-54-1)
- 2-Amino-7-(2,3,4-trimethoxyphenyl)-7,8-dihydroquinazolin-5(6H)-one (CAS 1428139-04-1)
- 2-Bromo-3-(difluoromethyl)-6-fluoroisonicotinic acid (CAS 1805398-12-2)
- 3-Chloro-5-hydroxy-4-iodobenzoic acid (CAS 2385054-24-8)
- Ethyl 4-hydroxy-1H-pyrazole-3-carboxylate (CAS 1500974-00-4)
- 2H-Benzo[b][1,4]dioxepin-3(4H)-one (CAS 27612-17-5)
- D-Pro36-Tirzepatide (CAS CATO-CPTD788903)
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