4-(Trifluoromethyl)pyridine 1-oxide CAS 22253-59-4
| CAS No. | 22253-59-4 |
| Molecular Formula | C6H4F3NO |
| Molecular Weight | 163.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 163.10 g/mol gives 4-(Trifluoromethyl)pyridine 1-oxide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
4-(Trifluoromethyl)pyridine 1-oxide (CAS 22253-59-4) is a high-purity analytical reference standard with the molecular formula C6H4F3NO and a molecular weight of 163.10 g/mol.
Structurally, 4-(Trifluoromethyl)pyridine 1-oxide (C6H4F3NO) contains an amide group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 163.10 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-(Trifluoromethyl)pyridine 1-oxide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H4F3NO |
| Molecular Weight | 163.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- 4-(Trifluoromethyl)pyrimidin-5-amine (CAS 1092299-22-3)
- 5-(Trifluoromethyl)-1H-pyrrole-2-carbaldehyde (CAS 1367875-88-4)
- 3-(Trifluoromethyl)pyridin-4(1H)-one (CAS 140899-19-0)
- 5-(trifluoromethyl)-1H-pyrrole-3-carbaldehyde (CAS 1803567-44-3)
- 5-(Trifluoromethyl)pyrimidin-4-amine (CAS 1805131-89-8)
- 2-(Trifluoromethyl)pyridine 1-oxide (CAS 22253-71-0)
- 3-(Trifluoromethyl)pyridin-2-ol (CAS 22245-83-6)
- 6-(Trifluoromethyl)pyridin-3-ol (CAS 216766-12-0)
Recommended Standards
- 4-(Trifluoromethoxy)pyridine (CAS 514821-10-4)
- 4-Amino-6-(trifluoromethyl)pyrimidine (CAS 672-41-3)
- 4-(2H-tetrazol-5-yl)-1,2,5-oxadiazole-3-carbonitrile (CAS 890092-72-5)
- 5-Amino-2-(trifluoromethyl)pyrimidine (CAS 73418-87-8)
- 1-Chloro-7-fluoro-1,2,3,4-tetrahydronaphthalene (CAS 1082399-51-6)
- 4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-2-(trifluoromethyl)benzonitrile (CAS 406224-65-5)
- (R)-1-Benzylpiperidine-3-carboxylic acid (CAS 1030603-60-1)
- 3-Aminocarbonyl-2-fluorophenylboronic acid (CAS 1451392-76-9)
- Ethyl 4-amino-3-methylbutanoate hydrochloride (CAS 204503-79-7)
- N-(2-(4-Fluorophenoxy)ethyl)-2-(naphthalen-1-yl)acetamide (CAS 1105228-71-4)
- 9-Methyl-2-(methylsulfanyl)-4H-pyrido[1,2-a][1,3,5]triazin-4-one (CAS 306979-12-4)
- 3-(3-Ethoxyphenyl)-2-methylpropanoic acid (CAS 1017369-54-8)
- 22446-21-5 2-(Phenylthio)acetohydrazide MFCD00277524 (CAS 22446-21-5)
- Semaglutide impurity 267 (CAS CATO-C4X-2226267)
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