4-(Trifluoromethyl)pyrimidin-5-amine CAS 1092299-22-3
| CAS No. | 1092299-22-3 |
| Molecular Formula | C5H4F3N3 |
| Molecular Weight | 163.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-(Trifluoromethyl)pyrimidin-5-amine (C5H4F3N3) is characterized by a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
4-(Trifluoromethyl)pyrimidin-5-amine (CAS 1092299-22-3) is a high-purity analytical reference standard with the molecular formula C5H4F3N3 and a molecular weight of 163.10 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4-(Trifluoromethyl)pyrimidin-5-amine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C5H4F3N3 |
| Molecular Weight | 163.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Trifluoromethyl Standards
- 5-(Trifluoromethyl)-1H-pyrrole-2-carbaldehyde (CAS 1367875-88-4)
- 3-(Trifluoromethyl)pyridin-4(1H)-one (CAS 140899-19-0)
- 5-(trifluoromethyl)-1H-pyrrole-3-carbaldehyde (CAS 1803567-44-3)
- 5-(Trifluoromethyl)pyrimidin-4-amine (CAS 1805131-89-8)
- 2-(Trifluoromethyl)pyridine 1-oxide (CAS 22253-71-0)
- 3-(Trifluoromethyl)pyridin-2-ol (CAS 22245-83-6)
- 4-(Trifluoromethyl)pyridine 1-oxide (CAS 22253-59-4)
- 6-(Trifluoromethyl)pyridin-3-ol (CAS 216766-12-0)
Recommended Standards
- Methyl(2,2,3,3,3-pentafluoropropyl)amine (CAS 425-73-0)
- 3-Amino-2,4,6-trifluorophenol (CAS 113512-72-4)
- 2-((Carboxymethoxy)amino)-2-oxoacetic acid (CAS 177902-90-8)
- 3-Amino-5-(trifluoromethyl)pyridazine (CAS 1211591-88-6)
- (1R,2S)-2-Aminocyclooctanecarboxylic acid (CAS 522644-04-8)
- 4-Bromo-5-chloro-2-fluorobenzaldehyde (CAS 1603584-72-0)
- Ethyl (S)-2-(6-hydroxybenzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylate (CAS 135251-85-3)
- N-tert-Butyl-1-(4-cyanophenyl)methanesulfonamide (CAS 1041602-66-7)
- 3-Chloro-4-((trimethylsilyl)ethynyl)aniline (CAS 1533424-84-8)
- 4-Methyl-2,1,3-benzothiadiazole (CAS 1457-92-7)
- (2E)-3-(2,4-Dimethoxyphenyl)-1-(3-methoxyphenyl)prop-2-en-1-one (CAS 219298-57-4)
- 4-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)-N'-(3-(trifluoromethyl)picolinoyl)benzenesulfonohydrazide (CAS 1092346-40-1)
- 5-Methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-ol (CAS 2243236-30-6)
- Semaglutide Impurity 130 (CAS 1188328-40-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com