Tenofovir disoproxil Impurity 55 CAS 180587-75-1
| CAS No. | 180587-75-1 |
| Molecular Formula | C13H22N5O4P |
| Molecular Weight | 343.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Tenofovir disoproxil Impurity 55 (CAS 180587-75-1, C13H22N5O4P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Tenofovir disoproxil Impurity 55 (C13H22N5O4P) contains a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 5.5, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 343.32 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Tenofovir disoproxil Impurity 55 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H22N5O4P |
| Molecular Weight | 343.32 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2008 |
| Nitrogen Atoms | 5 |
Related Tenofovir Standards
- Tenofovir disoproxil Impurity 122 (CAS 1217630-57-3)
- Tenofovir Impurity 113 (CAS 1335287-28-9)
- Tenofovir disoproxil Impurity 115 (CAS CATO-C4X-1076115)
- Tenofovir Disoproxil Impurity 46 (CAS CATO-C4X-107646)
- Tenofovir disoproxil Impurity 124 (CAS CATO-C4X-1076124)
- Tenofovir Impurity 64 (CAS CATO-C4X-107664)
- Tenofovir Alafenamide Impurity 23 (CAS CATO-C4X-179723)
- Tenofovir Alafenamide Impurity 18 (CAS 379270-35-6)
Recommended Standards
- Bauhinin (CAS 100757-58-2)
- (2S,4S)-1-(tert-Butoxycarbonyl)-4-(2,4-difluoro-phenoxy)-2-pyrrolidinecarboxylic acid 317357-33-8 (CAS 317357-33-8)
- methyl 1-(2-ethoxy-2-oxoethyl)-6-(2-furyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (CAS 1011398-34-7)
- N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)phenyl)acetamide (CAS 339105-01-0)
- Linagliptin impurity 154 (CAS 1383917-84-7)
- Cholecalciferol Impurity 32 (CAS 89231-92-5)
- Aripiprazole EP Impurity F (CAS 573691-09-5)
- (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-chloro-4-fluorophenyl)propanoic acid (CAS 1217789-59-7)
- (E)-1-benzyl-5-((dimethylamino)methylene)-3,3-difluoropiperidin-4-one (CAS 1630062-35-9)
- Ethyl 6-(chloromethyl)-4-(4-fluorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (CAS 1260906-12-4)
- 1-Bromo-4-isocyanato-2-(trifluoromethyl)benzene (CAS 41513-02-4)
- (S)-8-Fluorochroman-4-amine (CAS 1003887-62-4)
- methyl 2-(isopropylamino)acetate (CAS 10552-78-0)
- (Thr(PO3H2)231)-Tau Peptide (225-237) trifluoroacetate salt (CAS 1670270-09-3)
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