Tenofovir Disoproxil Impurity 46 CAS CATO-C4X-107646
| CAS No. | CATO-C4X-107646 |
| Molecular Formula | C13H21O6PS |
| Molecular Weight | 336.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Tenofovir Disoproxil Impurity 46 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Tenofovir Disoproxil Impurity 46 (CAS CATO-C4X-107646, C13H21O6PS) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Tenofovir Disoproxil Impurity 46 (C13H21O6PS) is characterized by a sulfone group, a phosphate ester group, a carboxylic acid group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C13H21O6PS |
| Molecular Weight | 336.34 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| Sulfur Atoms | 1 |
Related Tenofovir Standards
- Tenofovir disoproxil Impurity 124 (CAS CATO-C4X-1076124)
- Tenofovir disoproxil Impurity 122 (CAS 1217630-57-3)
- Tenofovir disoproxil Impurity 55 (CAS 180587-75-1)
- Tenofovir Impurity 64 (CAS CATO-C4X-107664)
- Tenofovir Impurity 113 (CAS 1335287-28-9)
- Tenofovir disoproxil Impurity 115 (CAS CATO-C4X-1076115)
- Tenofovir disoproxil Impurity 86 (CAS 31618-90-3)
- Tenofovir Impurity 69 (CAS 1878175-74-6)
Recommended Standards
- (2R,3S,5R,6R,7R,8R)-2-Hydroxy-12-isopropenyl-7-methyl-11-oxospiro[4,10-dioxatetracyclo[7.2.1.02,7.03,5]dodecane-6,2\'-oxiran]-8-yl acetate 2749-28-2 (CAS 2749-28-2)
- Tadalafil Impurity 56 (CAS 406938-39-4)
- α-Fructose L-Arginine (CAS 25020-14-8)
- Tadalafil impurity 97 (CAS CATO-C4X-108797)
- Methylene blue /Methylthioninium Chloride Impurity 22 (CAS 34185-23-4)
- Fluvastatin Impurity 20 (CAS 1025064-18-9)
- Rosuvastatin Impurity 156 (CAS CATO-C4X-1169156)
- 2-(1H-Benzo[d]imidazole-2-carboxamido)benzoic acid (CAS 90700-70-2)
- 1-[4-(Propane-2-sulfonyl)phenyl]piperazine (CAS 1048921-11-4)
- 2-[(2,4,6-Trichlorophenyl)amino]-2,3,3a,4,7,7a-hexahydro-1H-isoindole-1,3-dione (CAS 350680-03-4)
- 3-Ethyl-7-methoxyquinoline-2-thiol (CAS 604754-98-5)
- 1-Methyl-1,2,3,4-tetrahydroquinoline-4-carbonitrile (CAS 72594-75-3)
- 6-Bromo-3-chloro-2,4-difluorobenzaldehyde (CAS 1160573-22-7)
- Tirzepatide Impurity 21 X TFA Salt (CAS CATO-C4X-324021)
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