Dapagliflozin Impurity 12 CAS 1807632-93-4
| CAS No. | 1807632-93-4 |
| Molecular Formula | C15H14Br2O |
| Molecular Weight | 370.08 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Dapagliflozin Impurity 12 (C15H14Br2O) contains a hydroxyl group, an ether linkage, bromine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies Dapagliflozin Impurity 12 (CAS 1807632-93-4), a pharmacopoeial impurity reference standard (molecular formula C15H14Br2O, MW 370.08 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Dapagliflozin Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H14Br2O |
| Molecular Weight | 370.08 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Br-containing |
Related Dapagliflozin Standards
- Dapagliflozin Impurity 143 (CAS CATO-C4X-1138143)
- Dapagliflozin Impurity 200 (CAS CATO-C4X-1138200)
- Dapagliflozin Impurity 180 (CAS CATO-C4X-1138180)
- Dapagliflozin Impurity 127 (CAS CATO-C4X-1138127)
- Dapagliflozin Impurity 128 (CAS CATO-C4X-1138128)
- Dapagliflozin Impurity 26 (CAS 2305949-36-2)
- Dapagliflozin Impurity 68 (CAS 1103738-29-9)
- Dapagliflozin Impurity 129 (CAS CATO-C4X-1138129)
Recommended Standards
- 4-Methylsulfonyl-2,3',4',5-tetrachlorobiphenyl (CAS 69797-51-9)
- 4-Methylsulfonyl-2,2',5,5'-tetrachlorobiphenyl (CAS 60640-55-3)
- 4-Methylsulfonyl-2,2',4',5-tetrachlorobiphenyl (CAS 69797-52-0)
- Glycerol Impurity 38 (CAS CATO-C4X-217138)
- Parecoxib Impurity 41 (CAS 198470-82-5)
- Icatibant Impurity 2 TFA salt (CAS CATO-C4X-23612)
- Degarelix Impurity 3 (CAS 2648486-37-5)
- 2-(1-Methyl-1H-pyrrol-2-yl)-N'-(2-(trifluoromethyl)benzylidene)acetohydrazide (CAS 314070-97-8)
- 3-(4-Chlorophenyl)-1-(6-chloropyridin-2-yl)-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine (CAS 303152-01-4)
- 3-(3-(4-Amino-1,2,5-oxadiazol-3-yl)-1,2,4-oxadiazol-5-yl)propanoic acid (CAS 881609-34-3)
- 2-(2-Bromo-4-formyl-6-methoxyphenoxy)acetamide (CAS 692268-00-1)
- 5-(3-Bromophenyl)-4H-1,2,4-triazol-3-amine (CAS 383130-99-2)
- 1,4-Bis(3-formylphenylethynyl)benzene (CAS 909103-56-6)
- (Glu9)-Exenatide (2-39) trifluoroacetate salt (CAS 196109-34-9)
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