Dapagliflozin Impurity 26 CAS 2305949-36-2
| CAS No. | 2305949-36-2 |
| Molecular Formula | C15H14ClIO |
| Molecular Weight | 372.63 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Dapagliflozin Impurity 26 (CAS 2305949-36-2, C15H14ClIO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Dapagliflozin Impurity 26 (C15H14ClIO) is characterized by a hydroxyl group, an ether linkage, chlorine/iodine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Dapagliflozin Impurity 26 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H14ClIO |
| Molecular Weight | 372.63 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Cl/I-containing |
Related Dapagliflozin Standards
- Dapagliflozin Impurity 127 (CAS CATO-C4X-1138127)
- Dapagliflozin Impurity 128 (CAS CATO-C4X-1138128)
- Dapagliflozin Impurity 68 (CAS 1103738-29-9)
- Dapagliflozin Impurity 129 (CAS CATO-C4X-1138129)
- Dapagliflozin Impurity 180 (CAS CATO-C4X-1138180)
- Dapagliflozin Impurity 32 (CAS 2452300-89-7)
- Dapagliflozin Impurity 12 (CAS 1807632-93-4)
- Dapagliflozin Impurity 143 (CAS CATO-C4X-1138143)
Recommended Standards
- 5-Bromo-2-chloro-7-(1,4-dioxaspiro[4.5]Decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidine (CAS 1638772-29-8)
- Empagliflozin impurity 208 (CAS CATO-C4X-1065208)
- (E)-1,2-Bis(4-fluoro-5-(trimethylsilyl)thiophen-2-yl)ethene (CAS 2205860-41-7)
- Empagliflozin Impurity 102 (CAS CATO-C4X-1065102)
- Dexmedetomidine Impurity 36 (CAS 86347-14-0)
- Metoclopramide impurity 70 (CAS 102313-35-9)
- Losartan Impurity 44 (CAS CATO-C4X-168344)
- 1,6-Dimethylpyrazin-2(1H)-one (CAS 137232-62-3)
- (R)-5-Hydroxy-1,7-diphenyl-3-heptanone (CAS 100761-20-4)
- 4-(2-fluoro-3-methoxyphenyl)piperidine hydrochloride (CAS 1803581-18-1)
- N-(Amino-PEG3)-N-bis(PEG4-Boc) (CAS 2353409-57-9)
- 5-Chloropyrido[3,4-d]pyridazin-4(3H)-one (CAS 1824466-35-4)
- tert-Butyl (5-fluoroazepan-4-yl)carbamate (CAS 1428576-41-3)
- Semaglutide impurity 78 (CAS CATO-C4X-222678)
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